Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: Comparison with echovirus type 30 meningitis

• Published in: Cytokine (Philadelphia, Pa.) Pa.), 2005-06, Vol.30 (5), p.243-247
• Main Authors: Ichiyama, Takashi, Maeba, Shinji, Suenaga, Naoko, Saito, Kumiko, Matsubara, Tomoyo, Furukawa, Susumu
• Format: Article
• Language: English
• Subjects: Adolescent; Cerebrospinal fluid; Child; Child, Preschool; Cytokine; Cytokines - cerebrospinal fluid; Echovirus; Echovirus type 30 meningitis; Enterovirus B, Human - physiology; Enterovirus Infections - cerebrospinal fluid; Enterovirus Infections - virology; Female; Humans; Infant; Male; Meningitis, Viral - cerebrospinal fluid; Meningitis, Viral - virology; Mumps - cerebrospinal fluid; Mumps - virology; Mumps meningitis; Mumps virus; Mumps virus - physiology
• ISSN: 1043-4666; 1096-0023
• DOI: 10.1016/j.cyto.2005.01.022

It is unclear whether or not the CSF cytokine profiles in viral meningitis differ with the kind of causative virus. We measured the concentrations of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-4, IL-6, and IL-10 in CSF during the acute stage in 15 children with mumps meningitis (MM), and 34 with echovirus type 30 meningitis (EM). The CSF IFN-γ, IL-2, IL-6, and IL-10 levels were elevated in MM, and the CSF IFN-γ, IL-2, and IL-6 levels were elevated in EM. The CSF IFN-γ, IL-2, and IL-10 levels in MM were significantly higher than those in EM ( p < 0.0001, p < 0.0001, and p < 0.0001, respectively). The CSF IL-6 levels in EM were significantly higher than those in MM ( p = 0.0255). The CSF TNF-α and IL-4 levels were not elevated in MM or EM. In MM, the IL-6 level was correlated with the IL-2 and IL-10 levels in CSF ( p = 0.0347 and p = 0.0120, respectively). In EM, the IFN-γ level was correlated with the IL-10 level in CSF ( p = 0.0002). CSF cytokine profiles in MM were different from those in EM. Therefore, it is likely that the pathogenesis of MM is different from that of EM.