Numbing the Senses: Role of TRPA1 in Mechanical and Cold Sensation

In this issue of Neuron, Kwan et al. demonstrate that TRPA1 is critical for the transduction of noxious cold and mechanical stimuli, as well as in mediating the activation of nociceptors by endogenous and natural irritants. Differences between the present report and a previous study indicate that fu...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2006-04, Vol.50 (2), p.177-180
Main Authors: Story, Gina M., Gereau, Robert W.
Format: Article
Language:English
Subjects:
Animals
Behavior
Cold
Cold Temperature
Humans
Mechanotransduction, Cellular - physiology
Neurons
Pain
Pain - physiopathology
Physical Stimulation
Proteins
Rodents
Signal Transduction - physiology
Studies
Transient Receptor Potential Channels - physiology
TRPA1 Cation Channel
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Summary:In this issue of Neuron, Kwan et al. demonstrate that TRPA1 is critical for the transduction of noxious cold and mechanical stimuli, as well as in mediating the activation of nociceptors by endogenous and natural irritants. Differences between the present report and a previous study indicate that further study is needed to reach a consensus on the role of TRPA1 in the transduction of mechanical and noxious cold stimuli.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2006.04.009