Dysregulation of proinflammatory and regulatory cytokines in HIV infected persons with active tuberculosis

Proinflammatory and regulatory cytokines have been implicated to play important role in immunopathology of HIV and tuberculosis (TB) infection. Capacity of unstimulated and mitogen-stimulated peripheral blood mononuclear cells (PBMCs) to secrete cytokines (interleukin (IL)-2, interferon-γ (IFN-γ), t...

Full description

Saved in:
Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2005-06, Vol.30 (5), p.275-281
Main Authors: Bal, Abhijit M., Lakhashe, Samir K., Thakar, Madhuri R., Tripathy, Srikanth P., Paranjape, Ramesh S.
Format: Article
Language:English
Subjects:
Adult
Cells, Cultured
Coinfection
Cytokine
Cytokines - metabolism
Female
HIV
HIV - physiology
HIV Infections - complications
HIV Infections - immunology
HIV Infections - microbiology
HIV Infections - pathology
Human immunodeficiency virus
Humans
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
Inflammation Mediators - metabolism
Male
Mycobacterium
Mycobacterium tuberculosis
Tuberculosis
Tuberculosis - complications
Tuberculosis - immunology
Tuberculosis - pathology
Tuberculosis - virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Proinflammatory and regulatory cytokines have been implicated to play important role in immunopathology of HIV and tuberculosis (TB) infection. Capacity of unstimulated and mitogen-stimulated peripheral blood mononuclear cells (PBMCs) to secrete cytokines (interleukin (IL)-2, interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), IL-4, IL-10 and IL-6) was estimated for 15 HIV–TB coinfected patients, 22 HIV seropositives without TB, 32 HIV negative TB patients, and 36 healthy subjects. Dually infected patients had suppression of both Th1 and Th2 cytokine secretion as evidenced by significantly lower production of IL-2, IFN-γ and TNF-α as well as IL-4 and IL-10. Production of IL-2 and TNF-α was significantly decreased only in case of HIV infection. Significantly higher IL-6 secretion was found in unstimulated cultures in dually infected patients. The mitogen induced cytokine secretion was generally lower in HIV–TB coinfected patients indicating profound perturbation of both Th1 and Th2 responses.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2005.01.015