Dynamic Combinatorial Chemistry: The Unexpected Choice of Receptors by Guest Molecules

Survival of the fittest? Amplification of the best receptor from a dynamic combinatorial library does not always proceed according to survival of the “fittest”. However, it has recently resulted in the discovery of some unexpected receptors for various substrates, as illustrated by the example of a...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2006-04, Vol.45 (17), p.2660-2663
Main Authors: de Bruin, Bas, Hauwert, Peter, Reek, Joost N. H.
Format: Article
Language:English
Subjects:
dynamic combinatorial chemistry
molecular recognition
receptors
supramolecular chemistry
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Summary:Survival of the fittest? Amplification of the best receptor from a dynamic combinatorial library does not always proceed according to survival of the “fittest”. However, it has recently resulted in the discovery of some unexpected receptors for various substrates, as illustrated by the example of a catenane receptor (see picture; green) for the neurotransmitter acetylcholine (red).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200504480