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Aldose Reductase Inhibitors from the Fruiting Bodies of Ganoderma applanatum

The isolation and characterization of rat lens aldose reductase (RLAR) inhibitors from the fruiting bodies of Ganoderma applanatum were conducted. Among the extracts and fractions from G. applanatum tested, the MeOH extract and EtOAc fraction were found to exhibit potent RLAR inhibition in vitro, th...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2005, Vol.28(6), pp.1103-1105
Main Authors: Lee, Sanghyun, Shim, Sang Hee, Kim, Ju Sun, Shin, Kuk Hyun, Kang, Sam Sik
Format: Article
Language:English
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Summary:The isolation and characterization of rat lens aldose reductase (RLAR) inhibitors from the fruiting bodies of Ganoderma applanatum were conducted. Among the extracts and fractions from G. applanatum tested, the MeOH extract and EtOAc fraction were found to exhibit potent RLAR inhibition in vitro, their IC50 being 1.7 and 0.8 μg/ml, respectively. From the active EtOAc fraction, seven compounds with diverse structural moieties were isolated and identified as D-mannitol (1), 2-methoxyfatty acids (2), cerebrosides (3), daucosterol (4), 2,5-dihydroxyacetophenone (5), 2,5-dihydroxybenzoic acid (6), and protocatechualdehyde (7). Among them, protocatechualdehyde (7) was found to be the most potent RLAR inhibitor (IC50=0.7 μg/ml), and may be useful for the prevention and/or treatment of diabetic complications.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.1103