Genotyping of pathogenic Acanthamoebae isolated from clinical samples in Greece—Report of a clinical isolate presenting T5 genotype

Amoebae belonging to the genus Acanthamoeba are potentially pathogenic to humans, causing mainly amoebic keratitis. Pathogenic ability of the 15 known Acanthamoeba genotypes is under investigation. We report that four out of five cases of amoebic keratitis studied in Greece, present T4 sequence type...

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Bibliographic Details
Published in:Parasitology international 2006-06, Vol.55 (2), p.147-149
Main Authors: Spanakos, G., Tzanetou, K., Miltsakakis, D., Patsoula, E., Malamou-Lada, E., Vakalis, N.C.
Format: Article
Language:English
Subjects:
Acanthamoeba
Acanthamoeba - classification
Acanthamoeba - genetics
Acanthamoeba - isolation & purification
Acanthamoeba Keratitis - epidemiology
Acanthamoeba Keratitis - parasitology
Acanthamoeba lenticulata
Animals
Base Sequence
Genotype
Genotyping
Greece
Greece - epidemiology
Humans
Molecular Sequence Data
Phylogeny
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Summary:Amoebae belonging to the genus Acanthamoeba are potentially pathogenic to humans, causing mainly amoebic keratitis. Pathogenic ability of the 15 known Acanthamoeba genotypes is under investigation. We report that four out of five cases of amoebic keratitis studied in Greece, present T4 sequence type, while the remaining one presents T5 sequence type ( Acanthamoeba lenticulata), which is the second most frequent genotype found among environmental samples. Thus, it is confirmed, for the first time to our knowledge, that A. lenticulata can cause keratitis. However the reason that it is under represented in clinical samples compared to environmental ones is unknown.
ISSN:1383-5769
1873-0329
DOI:10.1016/j.parint.2005.12.001