Effects of intervertebral disc infection on the developing ovine spine

• Published in: Spine (Philadelphia, Pa. 1976) Pa. 1976), 2005-06, Vol.30 (11), p.1252-1257
• Main Authors: WALTERS, Rebecca M, SMITH, Samantha H. E, HUTCHINSON, M. John, DOLAN, A. Mark, FRASER, Robert D, MOORE, Robert J
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Cerebrospinal fluid. Meninges. Spinal cord; Discitis - diagnostic imaging; Discitis - microbiology; Discitis - pathology; Disease Models, Animal; Diseases of the osteoarticular system; Diseases of the spine; Growth Plate - growth & development; Growth Plate - microbiology; Growth Plate - pathology; Human viral diseases; Infectious diseases; Intervertebral Disc - growth & development; Intervertebral Disc - microbiology; Intervertebral Disc - pathology; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Prospective Studies; Radiography; Sheep; Spine - diagnostic imaging; Spine - growth & development; Spine - pathology; Staphylococcal Infections - complications; Staphylococcal Infections - pathology; Staphylococcus epidermidis; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids
• ISSN: 0362-2436; 1528-1159
• DOI: 10.1097/01.brs.0000164102.31726.0a

A prospective in vivo animal study. To determine whether infection in the juvenile spine influences spinal development. Discitis is thought to occur in children when blood-borne infection penetrates the highly vascular immature disc. The condition generally resolves without apparent complication, but little is known about the long-term effects on the growing spine. Twenty-nine 6-week-old lambs underwent discography at multiple lumbar levels using radiographic contrast deliberately inoculated with Staphylococcus epidermidis. No antibiotics were given. Plain radiographs were taken at intervals up to 52 weeks after inoculation for morphometric analysis of the vertebral bodies and discs, and the lumbar spines were prepared for histology. Sixteen of 44 inoculated discs showed radiological evidence of discitis between 2 and 6 weeks after inoculation. Disc height and disc area were significantly reduced from 2 weeks, and did not recover during the study period. Vertebral body dimensions and overall lumbar spine length were not significantly affected. Infection of juvenile ovine discs impedes disc development but has no significant effect on vertebral body growth.