Activity-dependent Synaptic Wnt Release Regulates Hippocampal Long Term Potentiation

Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-d-aspartate receptor-dependent synaptic Wnt3a release, nuclear β-catenin accumulations, and the activation of Wnt t...

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Bibliographic Details
Published in:The Journal of biological chemistry 2006-04, Vol.281 (17), p.11910-11916
Main Authors: Chen, Jianyong, Park, Chang Sin, Tang, Shao-Jun
Format: Article
Language:English
Subjects:
Action Potentials
Animals
beta Catenin - metabolism
Cell Nucleus - metabolism
Hippocampus - metabolism
Long-Term Potentiation
Mice
Neurons - metabolism
Signal Transduction
Synaptic Transmission
Wnt Proteins - metabolism
Wnt3 Protein
Wnt3A Protein
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Summary:Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-d-aspartate receptor-dependent synaptic Wnt3a release, nuclear β-catenin accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation. These findings suggest that Wnt signaling plays a critical role in regulating synaptic plasticity.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.M511920200