Evaluation of anxiolytic activity of spray dried powders of two South Brazilian Passiflora species

The Passiflora extracts have been used in folk medicine because of its reputed sedative and anxiolytic properties. The present study aimed to compare the potential anxiolytic activity of two Passiflora spray‐dried powders obtained from P. alata and P. edulis, known in Brazil as ‘maracujá’. Male adul...

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Bibliographic Details
Published in:Phytotherapy research 2006-05, Vol.20 (5), p.348-351
Main Authors: Reginatto, Flávio H., De-Paris, Fernanda, Petry, Raquel D., Quevedo, João, Ortega, George González, Gosmann, Grace, Schenkel, Eloir P.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anti-Anxiety Agents - administration & dosage
Anti-Anxiety Agents - pharmacology
Anti-Anxiety Agents - therapeutic use
anxiolytic activity
Behavior, Animal - drug effects
Biological and medical sciences
Brazil
Dose-Response Relationship, Drug
Drug Compounding
General pharmacology
Male
maracujá
Maze Learning - drug effects
Medical sciences
Medicine, Traditional
Passiflora
Passifloraceae
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
plus-maze test
Rats
Rats, Wistar
spray-dried powders
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Summary:The Passiflora extracts have been used in folk medicine because of its reputed sedative and anxiolytic properties. The present study aimed to compare the potential anxiolytic activity of two Passiflora spray‐dried powders obtained from P. alata and P. edulis, known in Brazil as ‘maracujá’. Male adult Swiss rats were treated with 200, 400 and 800 mg/kg of spray‐dried powders p.o. and anxiolytic activity was evaluated using the elevated plus‐maze test. The spray‐dried powders showed anxiolytic activity in doses of 400 and 800 mg/kg. Our results support the potential anxiolytic effect of Passiflora spray‐dried powders (P. alata and P. edulis). Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1853