Sweat-testing in preterm and full-term infants less than 6 weeks of age

• Published in: Pediatric pulmonology 2005-07, Vol.40 (1), p.64-67
• Main Authors: Eng, Warren, LeGrys, Vicky A., Schechter, Michael S., Laughon, Matthew M., Barker, Pierre M.
• Format: Article
• Language: English
• Subjects: African Americans; Biological and medical sciences; Body Weight; Chlorides - metabolism; Cystic Fibrosis - diagnosis; Cystic Fibrosis - metabolism; Female; full-term infants; Gestational Age; Humans; Infant; Infant, Newborn - metabolism; Infant, Premature - metabolism; Male; Mass Screening - methods; Medical sciences; Multivariate Analysis; Pneumology; preterm infants; Retrospective Studies; Risk Factors; Specimen Handling - methods; Sweat - metabolism; sweat chloride; sweat-testing
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.20235

Our objective was to examine the characteristics of preterm and full‐term infants ≤6 weeks old that influence the success of obtaining sufficient sweat for diagnosis of CF, and corresponding sweat chloride concentrations. A retrospective chart review of 119 sweat tests was performed on 103 preterm and full‐term infants ≤6 weeks of age. Bivariate and multivariate regression analyses were used to determine the predictors of successful sweat testing and characteristics influencing sweat chloride concentrations. Adequate amounts of sweat (≥75 mg) were obtained for analysis in 73.8% of initial attempts in the infant group. The following characteristics were associated with increased odds of obtaining a quantity not sufficient (QNS) for sweat chloride concentration measurement: African‐American race, infant weight