Positive Pressure Ventilation Treatment Reduces Plasma Levels of Amino Terminal-Pro Brain Natriuretic Peptide in Congestive Heart Failure Patients With Sleep Apnea

Background The purpose of the present study was to assess the short-term effects of positive pressure ventilation (PPV) on plasma amino terminal-pro brain natriuretic peptide (NT-proBNP) levels in patients with congestive heart failure (CHF) and sleep apnea (SA). Methods and Results Polysomnography...

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Published in:Circulation Journal 2006, Vol.70(5), pp.572-574
Main Authors: Zhao, Zhi-Hui, Liu, Zhi-Hong, Luo, Qin, Xiong, Chang-Ming, Ni, Xin-Hai, Zhang, Jian, Zhang, Shu, Yang, Yue-Jin
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Congestive heart failure
Female
Heart Failure - complications
Heart Failure - therapy
Humans
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Polysomnography
Positive pressure ventilation
Sleep apnea
Sleep Apnea Syndromes - etiology
Sleep Apnea Syndromes - therapy
Ventilation - standards
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Summary:Background The purpose of the present study was to assess the short-term effects of positive pressure ventilation (PPV) on plasma amino terminal-pro brain natriuretic peptide (NT-proBNP) levels in patients with congestive heart failure (CHF) and sleep apnea (SA). Methods and Results Polysomnography was performed in 105 CHF patients. Twenty-six patients with CHF and SA were randomly assigned to a control group or a PPV group. Patients in the higher New York Heart Association classes had higher plasma levels of NT-proBNP. The plasma NT-proBNP concentration in the PPV group decreased. Conclusion Plasma NT-proBNP levels reflect the severity of CHF, and PPV can decrease plasma NT-proBNP levels in patients with CHF and SA. (Circ J 2006; 70: 572 - 574)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.70.572