Development of drug intermediates by using direct organocatalytic multi-component reactions

Novel, economic and environmentally friendly one-pot three-component Knoevenagel/hydrogenation (K/H) and four-component Knoevenagel/hydrogenation/alkylation (K/H/A) reactions of ketones, CH-acids, dihydropyridines and alkyl halides using proline and proline/metal carbonate catalysis, respectively, h...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2006-01, Vol.4 (9), p.1641-1646
Main Authors: Ramachary, Dhevalapally B, Kishor, M, Reddy, G Babul
Format: Article
Language:English
Subjects:
Alkylation
Carboxylic Acids - chemistry
Catalysis
Chemistry, Pharmaceutical - methods
Dihydropyridines - chemistry
Hydrocarbons, Halogenated - chemistry
Hydrogenation
Ketones - chemistry
Pharmaceutical Preparations - chemical synthesis
Proline - chemistry
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Summary:Novel, economic and environmentally friendly one-pot three-component Knoevenagel/hydrogenation (K/H) and four-component Knoevenagel/hydrogenation/alkylation (K/H/A) reactions of ketones, CH-acids, dihydropyridines and alkyl halides using proline and proline/metal carbonate catalysis, respectively, have been developed. Many of the products of these K/H and K/H/A reactions have direct applications in pharmaceutical chemistry.
ISSN:1477-0520
1477-0539
DOI:10.1039/b602696f