Effects of Statins on Renal Function After Aortic Cross Clamping During Major Vascular Surgery

Ischemic reperfusion injury is an important cause of renal dysfunction after major vascular surgery and increases postoperative morbidity and mortality. The aim of the present study was to assess the effect of statins on renal function in patients at high risk for renal dysfunction, that is, those w...

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Bibliographic Details
Published in:The American journal of cardiology 2006-05, Vol.97 (9), p.1383-1385
Main Authors: Schouten, Olaf, Kok, Niels F.M., Boersma, Eric, Bax, Jeroen J., Feringa, Harm H.H., Vidakovic, Radosav, Statius van Eps, Randolph G., van Sambeek, Marc R.H.M., Poldermans, Don
Format: Article
Language:English
Subjects:
Aged
Aorta, Abdominal - surgery
Aortic Aneurysm, Abdominal - surgery
Biological and medical sciences
Cardiology. Vascular system
Constriction
Creatinine - blood
Female
Glomerular Filtration Rate
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Kidneys
Male
Medical sciences
Multivariate Analysis
Postoperative Care
Preoperative Care
Renal Dialysis - utilization
Statins
Vascular surgery
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Summary:Ischemic reperfusion injury is an important cause of renal dysfunction after major vascular surgery and increases postoperative morbidity and mortality. The aim of the present study was to assess the effect of statins on renal function in patients at high risk for renal dysfunction, that is, those who underwent suprarenal aortic cross clamping–declamping. Seventy-seven patients (28 statin users, 57 men; mean age 69 ± 8 years) with normal preoperative renal function requiring suprarenal aortic cross clamping–declamping during vascular surgery from 1995 to 2005 were studied. Creatinine levels were obtained before surgery and on days 1, 2, 3, 7, and 30 after surgery. An analysis-of-variance model for repeated measurements was applied to compare creatinine levels between statin users and nonusers, with adjustment for clamping time and blood loss. There were no differences in baseline clinical characteristics, preoperative creatinine levels (0.93 vs 0.96 mg/dl, p = 0.59), and glomerular filtration rate (79 vs 73 ml/min, p = 0.1). Postoperative creatinine levels during the 30 days after surgery were significantly lower in statin users than in nonusers (analysis-of-variance p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.11.063