Molecular Identification of an Invasive Gingival Bacterial Community

A woman with neutropenia developed gingival hyperplasia. Biopsy showed invasion of gingival tissue with mats of filamentous organisms, and molecular analysis by polymerase chain reaction and fluorescence in situ hybridization revealed Capnocytophaga sputigena, Leptotrichia species, and Fusobacterium...

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Bibliographic Details
Published in:Clinical infectious diseases 2005-07, Vol.41 (1), p.e1-e4
Main Authors: Fredricks, David N., Schubert, Mark M., Myerson, David
Format: Article
Language:English
Subjects:
Capnocytophaga - classification
Capnocytophaga - genetics
Capnocytophaga - isolation & purification
Capnocytophaga sputigena
DNA, Bacterial - analysis
DNA, Ribosomal - analysis
Female
Fusobacterium nucleatum
Fusobacterium nucleatum - classification
Fusobacterium nucleatum - genetics
Fusobacterium nucleatum - isolation & purification
Gingiva - microbiology
Gingival Hyperplasia - microbiology
Gram-Negative Bacterial Infections - microbiology
Humans
In Situ Hybridization, Fluorescence
Leptotrichia
Leptotrichia - classification
Leptotrichia - genetics
Leptotrichia - isolation & purification
Middle Aged
Neutropenia - complications
Polymerase Chain Reaction - methods
RNA, Ribosomal, 16S - genetics
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Summary:A woman with neutropenia developed gingival hyperplasia. Biopsy showed invasion of gingival tissue with mats of filamentous organisms, and molecular analysis by polymerase chain reaction and fluorescence in situ hybridization revealed Capnocytophaga sputigena, Leptotrichia species, and Fusobacterium nucleatum. Oral bacterial flora may cause invasive gingival disease with hyperplasia in immunocompromised patients.
ISSN:1058-4838
1537-6591
DOI:10.1086/430824