Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia

To investigate the hemodynamic and metabolic effects of the peroxisome proliferator-activated receptor (PPAR)-gamma ligand and nuclear-factor (NF)-kappa B inhibitor 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2) during long-term, hyperdynamic porcine endotoxemia. Prospective, randomized, controlled...

Full description

Saved in:
Bibliographic Details
Published in:Intensive care medicine 2006-05, Vol.32 (5), p.759-765
Main Authors: Hauser, Balázs, Kick, Jochen, Iványi, Zsolt, Asfar, Pierre, Ehrmann, Ulrich, Muth, Claus-Martin, Albicini, Maura, Wachter, Ulrich, Vogt, Josef, Bauer, Michael, Brückner, Uwe Bernd, Radermacher, Peter, Bracht, Hendrik
Format: Article
Language:English
Subjects:
Animals
Cyclopentanes
Endotoxemia - physiopathology
Europe
Hypotension - prevention & control
Immunologic Factors - administration & dosage
Immunologic Factors - pharmacology
Oxidative Stress
Prospective Studies
Prostaglandin D2 - administration & dosage
Prostaglandin D2 - analogs & derivatives
Prostaglandin D2 - pharmacology
Prostaglandins - metabolism
Random Allocation
Respiration, Artificial
Swine
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the hemodynamic and metabolic effects of the peroxisome proliferator-activated receptor (PPAR)-gamma ligand and nuclear-factor (NF)-kappa B inhibitor 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2) during long-term, hyperdynamic porcine endotoxemia. Prospective, randomized, controlled experimental study with repeated measures. Investigational animal laboratory. 19 anesthetized, mechanically ventilated and instrumented pigs. At 12 h of continuous intravenous endotoxin and hydroxyethylstarch to keep mean arterial pressure (MAP)>60 mmHg, swine randomly received vehicle (control group, n=10) or 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2 group, n=9; 1 microg kg(-1) min(-1) loading dose during 1 h; thereafter,0.25 microg kg(-1) min(-1) for 11 h). Hemodynamic, metabolic and organ function parameters were assessed together with parameters of nitric oxide production and oxidative stress. 15d-PGJ2 prevented the endotoxin-induced progressive hypotension, due to a positive inotropic effect, which resulted in a significantly higher blood pressure during the treatment phase and prevented the rise in hepatic vein alanine-aminotransferase activity. It did not affect, however, any other parameter of organ function nor of nitric oxide production, proinflammatory cytokine release or lipid peroxidation (8-isoprostane). 15d-PGJ2 stabilized systemic hemodynamics, due to improved myocardial performance, and resulted in an only transient effect on alanine-aminotransferase activity, without further beneficial effect on endotoxin-induced metabolic and organ function derangements. Low tissue 15d-PGJ2 concentrations and/or the delayed drug administration may explain these findings.
ISSN:0342-4642