Biomphalaria glabrata cytosolic copper/zinc superoxide dismutase ( SOD1) gene: Association of SOD1 alleles with resistance/susceptibility to Schistosoma mansoni

Variation in susceptibility of the snail Biomphalaria glabrata to infection by the parasite Schistosoma mansoni is, at least in part, genetically determined. Functional studies have demonstrated that hemocyte-mediated killing of the parasite involves hydrogen peroxide, the enzymatic product of super...

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Bibliographic Details
Published in:Molecular and biochemical parasitology 2006-06, Vol.147 (2), p.207-210
Main Authors: Goodall, Cheri P., Bender, Randall C., Brooks, Jana K., Bayne, Christopher J.
Format: Article
Language:English
Subjects:
Alleles
Animals
Biomphalaria - enzymology
Biomphalaria - immunology
Biomphalaria - parasitology
Biomphalaria glabrata
Copper - metabolism
Cytosol - enzymology
Hydrogen peroxide
Immunity, Innate
Molecular Sequence Data
Polymerase Chain Reaction
Resistance
Schistosoma mansoni
Schistosoma mansoni - pathogenicity
Sequence Analysis, DNA
Superoxide dismutase
Superoxide Dismutase - genetics
Superoxide Dismutase - metabolism
Zinc - metabolism
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Summary:Variation in susceptibility of the snail Biomphalaria glabrata to infection by the parasite Schistosoma mansoni is, at least in part, genetically determined. Functional studies have demonstrated that hemocyte-mediated killing of the parasite involves hydrogen peroxide, the enzymatic product of superoxide dismutase (SOD). The present study identifies alleles of the gene coding for cytosolic copper/zinc SOD (SOD1). The resistance/susceptibility phenotypes and SOD1 genotypes were determined for 354 snails of the predominantly resistant 13-16-R1 strain of B. glabrata. Resistance to the parasite was found to be significantly associated with one allele of the SOD1 gene. Conversely, a separate SOD1 allele was significantly associated with susceptibility.
ISSN:0166-6851
1872-9428
DOI:10.1016/j.molbiopara.2006.02.009