Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer

It has been speculated that IL‐1 genes play a crucial role in the genetic predisposition to duodenal ulcer upon H. pylori infection by modulating the host immune response. In the present study, 310 individuals from Eastern India were subjected to a case–control study to determine the IL1B and IL1RN...

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Bibliographic Details
Published in:Human mutation 2006-05, Vol.27 (5), p.411-419
Main Authors: Chakravorty, Meenakshi, Ghosh, Arunima, Choudhury, Abhijit, Santra, Amal, Hembrum, Jobaranjan, Roychoudhury, Susanta
Format: Article
Language:English
Subjects:
Acids
Bacterial infections
Councils
Cytokines
duodenal ulcer
Duodenal Ulcer - epidemiology
Duodenal Ulcer - genetics
Duodenal Ulcer - microbiology
Genes
Genetic Predisposition to Disease
Genomics
Genotype & phenotype
Haplotypes
Helicobacter Infections - complications
Helicobacter pylori
Helicobacter pylori - isolation & purification
Humans
IL1B
India - epidemiology
Indian population
Industrial research
Infections
interleukin 1 beta
Interleukin-1 - genetics
Interleukin-1beta
Intestinal Mucosa - metabolism
Mutation
Pathogenesis
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
RNA, Messenger - metabolism
SNP
Tumor Necrosis Factor-alpha - metabolism
Ulcers
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Summary:It has been speculated that IL‐1 genes play a crucial role in the genetic predisposition to duodenal ulcer upon H. pylori infection by modulating the host immune response. In the present study, 310 individuals from Eastern India were subjected to a case–control study to determine the IL1B and IL1RN risk genotypes to H. pylori mediated duodenal ulcer. An analysis of genotype frequency revealed a significantly higher frequency of IL1B −511TT (NT_022135.14:g.2302610C>T), OR=4.22 (95% CI=1.8−9.4) and −31CC (NT_022135.14:g.2302130C>T), OR=2.16 (95% CI 1.12−4.15) genotypes in H. pylori‐infected individuals with duodenal ulcer compared to infected individuals with normal mucosa. Moreover, the T/C haplotype of IL1B −511 and IL1B −31 loci was present in a significantly higher frequency in H. pylori‐infected duodenal ulcer patients than in infected controls (OR=2.47, CI=1.27−4.8). Quantitative analysis of the mucosal IL1B mRNA revealed that among H. pylori‐infected individuals, carriers of the −31CC genotype had significantly lower IL1B transcript levels than carriers of the CT (P
ISSN:1059-7794
1098-1004
DOI:10.1002/humu.20299