Increased [18F]Fluorodeoxyglucose Accumulation in Right Ventricular Free Wall in Patients With Pulmonary Hypertension and the Effect of Epoprostenol

• Published in: Journal of the American College of Cardiology 2005-06, Vol.45 (11), p.1849-1855
• Main Authors: Oikawa, Minako, Kagaya, Yutaka, Otani, Hiroki, Sakuma, Masahito, Demachi, Jun, Suzuki, Jun, Takahashi, Tohru, Nawata, Jun, Ido, Tatsuo, Watanabe, Jun, Shirato, Kunio
• Format: Article
• Language: English
• Subjects: Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular disease; Epoprostenol - pharmacology; Epoprostenol - therapeutic use; Female; Fluorodeoxyglucose F18 - metabolism; Glucose; Heart; Heart Ventricles - metabolism; Humans; Hypertension, Pulmonary - drug therapy; Hypertension, Pulmonary - metabolism; Hypertension, Pulmonary - physiopathology; Insulin; Intubation; Male; Medical imaging; Medical sciences; Middle Aged; NMR; Nuclear magnetic resonance; Peptides; Pneumology; Positron-Emission Tomography; Pulmonary arteries; Pulmonary hypertension; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Stroke Volume; Tomography; Vascular Resistance - drug effects; Ventricular Pressure
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2005.02.065

We examined whether right ventricular (RV) [18F]fluorodeoxyglucose (FDG) accumulation is increased in patients with pulmonary hypertension using gated positron emission tomography (PET) and whether RV FDG accumulation changes after therapy with epoprostenol. Myocardial glucose utilization is increased in animal models with ventricular pressure overload. We performed gated FDG-PET in 24 patients with pulmonary hypertension. The RV standardized uptake value (SUV) of FDG was corrected for the partial volume effect based on the wall thickness measured by electron-beam computed tomography or magnetic resonance imaging. The corrected RV SUV of FDG was significantly correlated with the pulmonary vascular resistance, mean pulmonary artery pressure, right atrial pressure, RV wall stress, and plasma brain natriuretic peptide levels, but not with the RV wall thickness and mass. After pulmonary vasodilator therapy with epoprostenol for three months, the corrected RV SUV of FDG significantly decreased in the responders, but not in the non-responders, and the percentage change of the corrected RV SUV of FDG was significantly correlated with the percentage change of the pulmonary vascular resistance (r = 0.78; p < 0.01) and RV systolic wall stress (r = 0.76; p < 0.05). The RV FDG accumulation corrected for the partial volume effect was significantly increased in accordance with the severity of the RV pressure overload (i.e., the RV peak-systolic wall stress) in patients with pulmonary hypertension. Furthermore, the corrected RV FDG accumulation was decreased after the treatment with epoprostenol in accordance with the degree of reduction in the pulmonary vascular resistance and RV peak-systolic wall stress.