Ocular lesions in Watanabe heritable hyperlipidemic rabbits

Hyperlipidemic ocular lesions are described for Watanabe heritable hyperlipidemic (WHHL) rabbits. Male WHHL rabbits 8 months old exhibited serum hyperlipidemia and ophthalmoscopically yellowish‐white lesions along the corneoscleral junction and in the iris. Histopathologically, foamy macrophages agg...

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Bibliographic Details
Published in:Veterinary ophthalmology 2006-05, Vol.9 (3), p.145-148
Main Authors: Kouchi, Mami, Ueda, Yoshinaka, Horie, Hiroshi, Tanaka, Kohji
Format: Article
Language:English
Subjects:
Animals
choroid
Choroid - blood supply
Choroid - immunology
Choroid - pathology
Choroid Diseases - etiology
Choroid Diseases - immunology
Choroid Diseases - pathology
Choroid Diseases - veterinary
Ciliary Body - pathology
Cornea - pathology
Corneal Diseases - etiology
Corneal Diseases - pathology
Corneal Diseases - veterinary
Disease Models, Animal
Hyperlipidemias - complications
Hyperlipidemias - immunology
Hyperlipidemias - pathology
Hyperlipidemias - veterinary
hyperlipidemic
Immunohistochemistry - veterinary
Iris - pathology
Iris Diseases - etiology
Iris Diseases - pathology
Iris Diseases - veterinary
lipid keratopathy
Lipid Metabolism
Macrophages
Male
ocular lesion
Rabbits
sclera
Sclera - blood supply
Sclera - immunology
Sclera - pathology
Scleral Diseases - etiology
Scleral Diseases - immunology
Scleral Diseases - pathology
Scleral Diseases - veterinary
Watanabe heritable hyperlipidemic rabbit
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Description
Summary:Hyperlipidemic ocular lesions are described for Watanabe heritable hyperlipidemic (WHHL) rabbits. Male WHHL rabbits 8 months old exhibited serum hyperlipidemia and ophthalmoscopically yellowish‐white lesions along the corneoscleral junction and in the iris. Histopathologically, foamy macrophages aggregated in the stroma of the cornea, iris, and ciliary body were observed. These findings have been interpreted as lipid keratopathy. In addition, multiple clusters of a large number of foamy macrophages occurred throughout the choroid and sclera in association with the blood vessels. The lesions in the choroid and sclera could not be detected ophthalmoscopy, yet were much more prominent than those in the cornea, iris, and ciliary body, suggesting greater involvement and earlier onset of lipidosis at these sites associated with hyperlipidemia in WHHL rabbits.
ISSN:1463-5216
1463-5224
DOI:10.1111/j.1463-5224.2006.00453.x