Iridium-Catalyzed Ring Cleavage Reaction of Cyclobutanone O-Benzoyloximes Providing Nitriles

Iridium-catalyzed ring cleavage reaction of cyclobutanone O-benzoyloximes in the presence of 9,10-dihydroanthracene and potassium carbonate proceeds to give saturated nitriles via C−C bond fission at the sterically more hindered site.

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Bibliographic Details
Published in:Organic letters 2005-06, Vol.7 (12), p.2425-2427
Main Authors: Nishimura, Takahiro, Yoshinaka, Tomoaki, Nishiguchi, Yoshiki, Maeda, Yasunari, Uemura, Sakae
Format: Article
Language:English
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Description
Summary:Iridium-catalyzed ring cleavage reaction of cyclobutanone O-benzoyloximes in the presence of 9,10-dihydroanthracene and potassium carbonate proceeds to give saturated nitriles via C−C bond fission at the sterically more hindered site.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0507120