The impact of anxiety and mood disorders on physical disease: the worried not-so-well

Depression and anxiety can adversely affect the course of chronic physical illnesses, increasing morbidity and mortality. The literature during the past year is reviewed for gastrointestinal disorders, cancer, pain, heart disease, diabetes, and pulmonary disease. Causes for this relationship are beh...

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Bibliographic Details
Published in:Current psychiatry reports 2005-06, Vol.7 (3), p.206-212
Main Authors: Sobel, Richard M, Markov, Dimitri
Format: Article
Language:English
Subjects:
Anxiety
Anxiety Disorders - complications
Anxiety Disorders - physiopathology
Anxiety Disorders - psychology
Chronic Disease - psychology
Comorbidity
Depressive Disorder - complications
Depressive Disorder - physiopathology
Depressive Disorder - psychology
Disease Progression
Health Behavior
Humans
Hypothalamo-Hypophyseal System - physiopathology
Mood disorders
Pituitary-Adrenal System - physiopathology
Prognosis
Psychiatry
Sick Role
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Summary:Depression and anxiety can adversely affect the course of chronic physical illnesses, increasing morbidity and mortality. The literature during the past year is reviewed for gastrointestinal disorders, cancer, pain, heart disease, diabetes, and pulmonary disease. Causes for this relationship are behavioral and biological. Behavioral factors in patients with depressive and anxiety disorders include unhealthy lifestyle choices, disrupted sleep, and poor adherence to medical regimens. Biological mechanisms include increased inflammatory response and disruption of the hypothalamic-pituitary-adrenal axis.
ISSN:1523-3812
1535-1645
DOI:10.1007/s11920-005-0055-y