Localization of the Human Cortical Visual Area MT Based on Computer Aided Histological Analysis

We describe human area MT histologically based on the observer independent analysis of cortical myeloarchiteture, multiple complementary staining techniques and 3-D reconstruction. The topography of an architectonic field that presented constant structural characteristics across specimens was studie...

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Bibliographic Details
Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2005-07, Vol.15 (7), p.1044-1053
Main Authors: Annese, J., Gazzaniga, M.S., Toga, A.W.
Format: Article
Language:English
Subjects:
architectonics
Cell Shape
Histocytochemistry
histology
Humans
Image Processing, Computer-Assisted
Immunohistochemistry
motion perception
Motion Perception - physiology
Pyramidal Cells - cytology
Staining and Labeling
Temporal Lobe - cytology
Temporal Lobe - physiology
visual cortex
Visual Cortex - cytology
Visual Cortex - physiology
Visual Pathways
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Summary:We describe human area MT histologically based on the observer independent analysis of cortical myeloarchiteture, multiple complementary staining techniques and 3-D reconstruction. The topography of an architectonic field that presented constant structural characteristics across specimens was studied in relation to the sulcal geography of the occipito-temporal region. Objective and semi-automated analysis of local microstructure revealed a distinct cortical architecture and matched topographically the localization of MT derived from functional imaging. MT was localized by the histotopographic method in relation to definite macroscopic landmarks. This study demonstrates a new set of distinguishing architectonic features of human MT that permit localization on structural grounds and suggests that the characteristic laminar structure of this area may be related to its unique pattern of connections and to its role in visual perception.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhh205