MR susceptometry for measuring global brain oxygen extraction

Monitoring of oxygen saturation in jugular venous blood gives an estimate of the balance of global oxygen delivery and cerebral oxygen consumption. We present a noninvasive approach to measure oxygen saturation in vivo in the internal jugular vein using MR susceptometry by exploiting the characteris...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2006-05, Vol.55 (5), p.967-973
Main Authors: Fernández-Seara, María A., Techawiboonwong, Aranee, Detre, John A., Wehrli, Felix W.
Format: Article
Language:English
Subjects:
Brain - metabolism
Feasibility Studies
field mapping
Humans
jugular vein
Jugular Veins - metabolism
Magnetic Resonance Imaging - instrumentation
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - instrumentation
Magnetic Resonance Spectroscopy - methods
Magnetics
MRI
Oximetry - methods
Oxygen - blood
Oxygen Consumption - physiology
oxygen saturation
Phantoms, Imaging
phase imaging
Reproducibility of Results
Sensitivity and Specificity
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Summary:Monitoring of oxygen saturation in jugular venous blood gives an estimate of the balance of global oxygen delivery and cerebral oxygen consumption. We present a noninvasive approach to measure oxygen saturation in vivo in the internal jugular vein using MR susceptometry by exploiting the characteristic susceptibility of deoxyhemoglobin, and demonstrate the feasibility of performing such measurements in a group of subjects. We assessed the sensitivity of the method for detecting small changes in oxygen saturation by monitoring the variations observed during breath‐holding and hypoventilation experiments. Unlike alternative methods, the susceptometric technique does not require calibration. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.20892