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Abnormal bone remodelling and increased levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) in Waldenström macroglobulinaemia
Summary Serum levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) and bone remodelling markers were evaluated in 38 patients with Waldenström macroglobulinaemia (WM) and correlated with clinical and laboratory variables. MIP‐1α was elevated in WM; untreated patients had higher MIP‐1α levels t...
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| Published in: | British journal of haematology 2006-05, Vol.133 (3), p.301-304 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c4477-f06d3c4bcb7df4d06672f5b7d915af51b9edb6dd7032e3bf89b6570bdb4cffb73 |
| container_end_page | 304 |
| container_issue | 3 |
| container_start_page | 301 |
| container_title | British journal of haematology |
| container_volume | 133 |
| creator | Terpos, Evangelos Anagnostopoulos, Athanasios Kastritis, Efstathios Bamias, Aristotelis Tsionos, Konstantinos Dimopoulos, Meletios‐Athanassios |
| description | Summary
Serum levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) and bone remodelling markers were evaluated in 38 patients with Waldenström macroglobulinaemia (WM) and correlated with clinical and laboratory variables. MIP‐1α was elevated in WM; untreated patients had higher MIP‐1α levels than patients in remission or with active disease after treatment. MIP‐1α correlated with increased bone resorption, β2‐microglobulin and splenomegaly. Receptor activator of nuclear factor‐κB ligand serum levels were elevated in WM patients; the subsequent increased bone resorption was balanced by a comparable elevation of osteoprotegerin production and bone formation. These findings may explain the absence of lytic lesions in WM patients and suggest a potential role of MIP‐1α in WM. |
| doi_str_mv | 10.1111/j.1365-2141.2006.06017.x |
| format | article |
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Serum levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) and bone remodelling markers were evaluated in 38 patients with Waldenström macroglobulinaemia (WM) and correlated with clinical and laboratory variables. MIP‐1α was elevated in WM; untreated patients had higher MIP‐1α levels than patients in remission or with active disease after treatment. MIP‐1α correlated with increased bone resorption, β2‐microglobulin and splenomegaly. Receptor activator of nuclear factor‐κB ligand serum levels were elevated in WM patients; the subsequent increased bone resorption was balanced by a comparable elevation of osteoprotegerin production and bone formation. These findings may explain the absence of lytic lesions in WM patients and suggest a potential role of MIP‐1α in WM.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2006.06017.x</identifier><identifier>PMID: 16643432</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; beta 2-Microglobulin - blood ; Biological and medical sciences ; Biomarkers - blood ; bone markers ; Bone Remodeling ; Bone Resorption - blood ; Bone Resorption - etiology ; Chemokine CCL3 ; Chemokine CCL4 ; Female ; Hematologic and hematopoietic diseases ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Macrophage Inflammatory Proteins - blood ; macrophage inflammatory protein‐1 alpha ; Male ; Medical sciences ; Middle Aged ; osteoprotegerin ; receptor activator of nuclear factor‐κB ligand ; Splenomegaly - blood ; Splenomegaly - etiology ; Waldenstrom Macroglobulinemia - blood ; Waldenstrom Macroglobulinemia - complications ; Waldenström macroglobulinaemia</subject><ispartof>British journal of haematology, 2006-05, Vol.133 (3), p.301-304</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4477-f06d3c4bcb7df4d06672f5b7d915af51b9edb6dd7032e3bf89b6570bdb4cffb73</citedby><cites>FETCH-LOGICAL-c4477-f06d3c4bcb7df4d06672f5b7d915af51b9edb6dd7032e3bf89b6570bdb4cffb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17660322$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16643432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terpos, Evangelos</creatorcontrib><creatorcontrib>Anagnostopoulos, Athanasios</creatorcontrib><creatorcontrib>Kastritis, Efstathios</creatorcontrib><creatorcontrib>Bamias, Aristotelis</creatorcontrib><creatorcontrib>Tsionos, Konstantinos</creatorcontrib><creatorcontrib>Dimopoulos, Meletios‐Athanassios</creatorcontrib><title>Abnormal bone remodelling and increased levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) in Waldenström macroglobulinaemia</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Serum levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) and bone remodelling markers were evaluated in 38 patients with Waldenström macroglobulinaemia (WM) and correlated with clinical and laboratory variables. MIP‐1α was elevated in WM; untreated patients had higher MIP‐1α levels than patients in remission or with active disease after treatment. MIP‐1α correlated with increased bone resorption, β2‐microglobulin and splenomegaly. Receptor activator of nuclear factor‐κB ligand serum levels were elevated in WM patients; the subsequent increased bone resorption was balanced by a comparable elevation of osteoprotegerin production and bone formation. These findings may explain the absence of lytic lesions in WM patients and suggest a potential role of MIP‐1α in WM.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>beta 2-Microglobulin - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>bone markers</subject><subject>Bone Remodeling</subject><subject>Bone Resorption - blood</subject><subject>Bone Resorption - etiology</subject><subject>Chemokine CCL3</subject><subject>Chemokine CCL4</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Macrophage Inflammatory Proteins - blood</subject><subject>macrophage inflammatory protein‐1 alpha</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>osteoprotegerin</subject><subject>receptor activator of nuclear factor‐κB ligand</subject><subject>Splenomegaly - blood</subject><subject>Splenomegaly - etiology</subject><subject>Waldenstrom Macroglobulinemia - blood</subject><subject>Waldenstrom Macroglobulinemia - complications</subject><subject>Waldenström macroglobulinaemia</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkb9uFDEQxi0EIsfBKyA3IFLsYq937buCIkQhCQqCAkRp-c_42JO9vth3kOuoqfIqNLxA-jwET4KXO5EWN_ZofjPz-RuEMCU1LeflsqaMd1VDW1o3hPCacEJFfXUPTf4l7qMJIURUlLSzA_Qo5yUhlJGOPkQHlPOWtayZoB9HeogpKI91HAAnCNGC9_2wwGqwuB9MApXBYg9fwWccHQ7KpLj6ohZQ0s6rENQ6pi1epbiGfvj9_Zpi5QuAX7w7_zCGtz8PC4o_K29hyOt08yvsuix81JsyTEHo1WP0wCmf4cn-nqJPb04-Hp9VF-9Pz4-PLirTtkJUjnDLTKuNFta1lnAuGteVYE475Tqq52A1t1YQ1gDTbjbXvBNEW90a57RgU_R817cIvtxAXsvQZ1M-rQaImyy5mJNZV-yZotkOLEpzTuDkKvVBpa2kRI57kEs52i1Hu-W4B_l3D_KqlD7dz9joAPaucG98AZ7tAZWN8i6pwfT5jhOcF_0j92rHfes9bP9bgHz99mx8sT90z6mh</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Terpos, Evangelos</creator><creator>Anagnostopoulos, Athanasios</creator><creator>Kastritis, Efstathios</creator><creator>Bamias, Aristotelis</creator><creator>Tsionos, Konstantinos</creator><creator>Dimopoulos, Meletios‐Athanassios</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Abnormal bone remodelling and increased levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) in Waldenström macroglobulinaemia</title><author>Terpos, Evangelos ; Anagnostopoulos, Athanasios ; Kastritis, Efstathios ; Bamias, Aristotelis ; Tsionos, Konstantinos ; Dimopoulos, Meletios‐Athanassios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4477-f06d3c4bcb7df4d06672f5b7d915af51b9edb6dd7032e3bf89b6570bdb4cffb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>beta 2-Microglobulin - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>bone markers</topic><topic>Bone Remodeling</topic><topic>Bone Resorption - blood</topic><topic>Bone Resorption - etiology</topic><topic>Chemokine CCL3</topic><topic>Chemokine CCL4</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Macrophage Inflammatory Proteins - blood</topic><topic>macrophage inflammatory protein‐1 alpha</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>osteoprotegerin</topic><topic>receptor activator of nuclear factor‐κB ligand</topic><topic>Splenomegaly - blood</topic><topic>Splenomegaly - etiology</topic><topic>Waldenstrom Macroglobulinemia - blood</topic><topic>Waldenstrom Macroglobulinemia - complications</topic><topic>Waldenström macroglobulinaemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terpos, Evangelos</creatorcontrib><creatorcontrib>Anagnostopoulos, Athanasios</creatorcontrib><creatorcontrib>Kastritis, Efstathios</creatorcontrib><creatorcontrib>Bamias, Aristotelis</creatorcontrib><creatorcontrib>Tsionos, Konstantinos</creatorcontrib><creatorcontrib>Dimopoulos, Meletios‐Athanassios</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terpos, Evangelos</au><au>Anagnostopoulos, Athanasios</au><au>Kastritis, Efstathios</au><au>Bamias, Aristotelis</au><au>Tsionos, Konstantinos</au><au>Dimopoulos, Meletios‐Athanassios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal bone remodelling and increased levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) in Waldenström macroglobulinaemia</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2006-05</date><risdate>2006</risdate><volume>133</volume><issue>3</issue><spage>301</spage><epage>304</epage><pages>301-304</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Serum levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) and bone remodelling markers were evaluated in 38 patients with Waldenström macroglobulinaemia (WM) and correlated with clinical and laboratory variables. MIP‐1α was elevated in WM; untreated patients had higher MIP‐1α levels than patients in remission or with active disease after treatment. MIP‐1α correlated with increased bone resorption, β2‐microglobulin and splenomegaly. Receptor activator of nuclear factor‐κB ligand serum levels were elevated in WM patients; the subsequent increased bone resorption was balanced by a comparable elevation of osteoprotegerin production and bone formation. These findings may explain the absence of lytic lesions in WM patients and suggest a potential role of MIP‐1α in WM.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16643432</pmid><doi>10.1111/j.1365-2141.2006.06017.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley |
| subjects | Adult Aged Aged, 80 and over beta 2-Microglobulin - blood Biological and medical sciences Biomarkers - blood bone markers Bone Remodeling Bone Resorption - blood Bone Resorption - etiology Chemokine CCL3 Chemokine CCL4 Female Hematologic and hematopoietic diseases Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Macrophage Inflammatory Proteins - blood macrophage inflammatory protein‐1 alpha Male Medical sciences Middle Aged osteoprotegerin receptor activator of nuclear factor‐κB ligand Splenomegaly - blood Splenomegaly - etiology Waldenstrom Macroglobulinemia - blood Waldenstrom Macroglobulinemia - complications Waldenström macroglobulinaemia |
| title | Abnormal bone remodelling and increased levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) in Waldenström macroglobulinaemia |
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