Multicentre study of hepatitis B virus genotypes in France: correlation with liver fibrosis and hepatitis B e antigen status

The clinical significance of hepatitis B virus (HBV) genotypes is still under debate. The aims of this study were to assess the distribution of HBV genotypes in France and to identify the associations between HBV genotypes and patient demographics, severity of liver disease and HBeAg status in patie...

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Bibliographic Details
Published in:Journal of viral hepatitis 2006-05, Vol.13 (5), p.329-335
Main Authors: Halfon, P., Bourlière, M., Pol, S., Benhamou, Y., Ouzan, D., Rotily, M., Khiri, H., Renou, C., Pénaranda, G., Saadoun, D., Thibault, V., Serpaggi, J., Varastet, M., Tainturier, M.-H., Poynard, T., Cacoub, P.
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Cross-Sectional Studies
epidemiology
Female
France
Genotype
hepatitis B
hepatitis B e antigen
Hepatitis B e Antigens - blood
Hepatitis B Surface Antigens - blood
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Hepatitis B, Chronic - enzymology
Hepatitis B, Chronic - immunology
Hepatitis B, Chronic - pathology
Hepatitis B, Chronic - virology
Histocytochemistry
Humans
Liver Cirrhosis - enzymology
Liver Cirrhosis - immunology
Liver Cirrhosis - pathology
liver fibrosis
Male
Middle Aged
Retrospective Studies
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Summary:The clinical significance of hepatitis B virus (HBV) genotypes is still under debate. The aims of this study were to assess the distribution of HBV genotypes in France and to identify the associations between HBV genotypes and patient demographics, severity of liver disease and HBeAg status in patients referred to tertiary care centres. This was a French, multicentre, retrospective study on 262 patients with chronic HBV infection. HBV genotypes were determined using INNO‐LiPA. Liver fibrosis damage was evaluated by histological analysis of biopsy samples. Patients were mainly male (74%), of Caucasian (65%), Asian (17%) or African (18%) ethnicity and 36% were HBeAg positive. All A–G genotypes were found, the most frequent being genotypes D (27%) and A (24%), followed by E (13%) and C (12%), and B (7%). Mixed genotypes were detected in 16% of the cases. Genotype A was associated with sexual contact (P 
ISSN:1352-0504
1365-2893
DOI:10.1111/j.1365-2893.2005.00692.x