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Multicentre study of hepatitis B virus genotypes in France: correlation with liver fibrosis and hepatitis B e antigen status
The clinical significance of hepatitis B virus (HBV) genotypes is still under debate. The aims of this study were to assess the distribution of HBV genotypes in France and to identify the associations between HBV genotypes and patient demographics, severity of liver disease and HBeAg status in patie...
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| Published in: | Journal of viral hepatitis 2006-05, Vol.13 (5), p.329-335 |
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| container_end_page | 335 |
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| container_title | Journal of viral hepatitis |
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| creator | Halfon, P. Bourlière, M. Pol, S. Benhamou, Y. Ouzan, D. Rotily, M. Khiri, H. Renou, C. Pénaranda, G. Saadoun, D. Thibault, V. Serpaggi, J. Varastet, M. Tainturier, M.-H. Poynard, T. Cacoub, P. |
| description | The clinical significance of hepatitis B virus (HBV) genotypes is still under debate. The aims of this study were to assess the distribution of HBV genotypes in France and to identify the associations between HBV genotypes and patient demographics, severity of liver disease and HBeAg status in patients referred to tertiary care centres. This was a French, multicentre, retrospective study on 262 patients with chronic HBV infection. HBV genotypes were determined using INNO‐LiPA. Liver fibrosis damage was evaluated by histological analysis of biopsy samples. Patients were mainly male (74%), of Caucasian (65%), Asian (17%) or African (18%) ethnicity and 36% were HBeAg positive. All A–G genotypes were found, the most frequent being genotypes D (27%) and A (24%), followed by E (13%) and C (12%), and B (7%). Mixed genotypes were detected in 16% of the cases. Genotype A was associated with sexual contact (P |
| doi_str_mv | 10.1111/j.1365-2893.2005.00692.x |
| format | article |
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The aims of this study were to assess the distribution of HBV genotypes in France and to identify the associations between HBV genotypes and patient demographics, severity of liver disease and HBeAg status in patients referred to tertiary care centres. This was a French, multicentre, retrospective study on 262 patients with chronic HBV infection. HBV genotypes were determined using INNO‐LiPA. Liver fibrosis damage was evaluated by histological analysis of biopsy samples. Patients were mainly male (74%), of Caucasian (65%), Asian (17%) or African (18%) ethnicity and 36% were HBeAg positive. All A–G genotypes were found, the most frequent being genotypes D (27%) and A (24%), followed by E (13%) and C (12%), and B (7%). Mixed genotypes were detected in 16% of the cases. Genotype A was associated with sexual contact (P < 0.001) and genotype D with transfusion (P < 0.001) and HBe antibody positivity (P = 0.03).The distribution of HBV genotypes differed with regard to the ethnicity, and may reflect migration patterns. Genotypes A and D were the most frequent in France. Genotype A was associated with HBeAg positivity and genotype D with HBe antibody positivity. In our European patients, we find no clear association between a given HBV genotype and liver disease severity.</description><identifier>ISSN: 1352-0504</identifier><identifier>EISSN: 1365-2893</identifier><identifier>DOI: 10.1111/j.1365-2893.2005.00692.x</identifier><identifier>PMID: 16637864</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Alanine Transaminase - blood ; Cross-Sectional Studies ; epidemiology ; Female ; France ; Genotype ; hepatitis B ; hepatitis B e antigen ; Hepatitis B e Antigens - blood ; Hepatitis B Surface Antigens - blood ; Hepatitis B virus ; Hepatitis B virus - genetics ; Hepatitis B virus - immunology ; Hepatitis B, Chronic - enzymology ; Hepatitis B, Chronic - immunology ; Hepatitis B, Chronic - pathology ; Hepatitis B, Chronic - virology ; Histocytochemistry ; Humans ; Liver Cirrhosis - enzymology ; Liver Cirrhosis - immunology ; Liver Cirrhosis - pathology ; liver fibrosis ; Male ; Middle Aged ; Retrospective Studies</subject><ispartof>Journal of viral hepatitis, 2006-05, Vol.13 (5), p.329-335</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4352-b7083ed8981cfa0d6519a2639333e8f97830857e82814a28cf464733ecfa7b1b3</citedby><cites>FETCH-LOGICAL-c4352-b7083ed8981cfa0d6519a2639333e8f97830857e82814a28cf464733ecfa7b1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16637864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Halfon, P.</creatorcontrib><creatorcontrib>Bourlière, M.</creatorcontrib><creatorcontrib>Pol, S.</creatorcontrib><creatorcontrib>Benhamou, Y.</creatorcontrib><creatorcontrib>Ouzan, D.</creatorcontrib><creatorcontrib>Rotily, M.</creatorcontrib><creatorcontrib>Khiri, H.</creatorcontrib><creatorcontrib>Renou, C.</creatorcontrib><creatorcontrib>Pénaranda, G.</creatorcontrib><creatorcontrib>Saadoun, D.</creatorcontrib><creatorcontrib>Thibault, V.</creatorcontrib><creatorcontrib>Serpaggi, J.</creatorcontrib><creatorcontrib>Varastet, M.</creatorcontrib><creatorcontrib>Tainturier, M.-H.</creatorcontrib><creatorcontrib>Poynard, T.</creatorcontrib><creatorcontrib>Cacoub, P.</creatorcontrib><title>Multicentre study of hepatitis B virus genotypes in France: correlation with liver fibrosis and hepatitis B e antigen status</title><title>Journal of viral hepatitis</title><addtitle>J Viral Hepat</addtitle><description>The clinical significance of hepatitis B virus (HBV) genotypes is still under debate. The aims of this study were to assess the distribution of HBV genotypes in France and to identify the associations between HBV genotypes and patient demographics, severity of liver disease and HBeAg status in patients referred to tertiary care centres. This was a French, multicentre, retrospective study on 262 patients with chronic HBV infection. HBV genotypes were determined using INNO‐LiPA. Liver fibrosis damage was evaluated by histological analysis of biopsy samples. Patients were mainly male (74%), of Caucasian (65%), Asian (17%) or African (18%) ethnicity and 36% were HBeAg positive. All A–G genotypes were found, the most frequent being genotypes D (27%) and A (24%), followed by E (13%) and C (12%), and B (7%). Mixed genotypes were detected in 16% of the cases. Genotype A was associated with sexual contact (P < 0.001) and genotype D with transfusion (P < 0.001) and HBe antibody positivity (P = 0.03).The distribution of HBV genotypes differed with regard to the ethnicity, and may reflect migration patterns. Genotypes A and D were the most frequent in France. Genotype A was associated with HBeAg positivity and genotype D with HBe antibody positivity. In our European patients, we find no clear association between a given HBV genotype and liver disease severity.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Cross-Sectional Studies</subject><subject>epidemiology</subject><subject>Female</subject><subject>France</subject><subject>Genotype</subject><subject>hepatitis B</subject><subject>hepatitis B e antigen</subject><subject>Hepatitis B e Antigens - blood</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B, Chronic - enzymology</subject><subject>Hepatitis B, Chronic - immunology</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Liver Cirrhosis - enzymology</subject><subject>Liver Cirrhosis - immunology</subject><subject>Liver Cirrhosis - pathology</subject><subject>liver fibrosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><issn>1352-0504</issn><issn>1365-2893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkVtv1DAQhS0Eohf4C8hPvCX1Jb4hXuiKbUEFJNTCo-UkE-olmyy20-5K_HgcdlXEE_jFo5nvnNHoIIQpKWl-Z6uScikKpg0vGSGiJEQaVm4foeOHweO5FqwgglRH6CTGFSGUM0GfoiMqJVdaVsfo54epT76BIQXAMU3tDo8dvoWNSz75iM_xnQ9TxN9gGNNuAxH7AS-DGxp4hZsxBOgzOQ743qdb3Ps7CLjzdRhjFruh_csKcif5bJU3uTTFZ-hJ5_oIzw__KbpZvr1eXBZXny7eLd5cFU01X1Arojm02mjadI60UlDjmOSGcw66M0pzooUCzTStHNNNV8lK5VmmVU1rfope7n03YfwxQUx27WMDfe8GGKdopTJEK1H9E6SKEWYIz6Deg02-NAbo7Cb4tQs7S4mdI7IrOydh5yTsHJH9HZHdZumLw46pXkP7R3jIJAOv98C972H338b2_ZfLXGR5sZf7mGD7IHfhe76TK2G_frywy_PPqlooYwX_BS5Arzo</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Halfon, P.</creator><creator>Bourlière, M.</creator><creator>Pol, S.</creator><creator>Benhamou, Y.</creator><creator>Ouzan, D.</creator><creator>Rotily, M.</creator><creator>Khiri, H.</creator><creator>Renou, C.</creator><creator>Pénaranda, G.</creator><creator>Saadoun, D.</creator><creator>Thibault, V.</creator><creator>Serpaggi, J.</creator><creator>Varastet, M.</creator><creator>Tainturier, M.-H.</creator><creator>Poynard, T.</creator><creator>Cacoub, P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Multicentre study of hepatitis B virus genotypes in France: correlation with liver fibrosis and hepatitis B e antigen status</title><author>Halfon, P. ; Bourlière, M. ; Pol, S. ; Benhamou, Y. ; Ouzan, D. ; Rotily, M. ; Khiri, H. ; Renou, C. ; Pénaranda, G. ; Saadoun, D. ; Thibault, V. ; Serpaggi, J. ; Varastet, M. ; Tainturier, M.-H. ; Poynard, T. ; Cacoub, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4352-b7083ed8981cfa0d6519a2639333e8f97830857e82814a28cf464733ecfa7b1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Cross-Sectional Studies</topic><topic>epidemiology</topic><topic>Female</topic><topic>France</topic><topic>Genotype</topic><topic>hepatitis B</topic><topic>hepatitis B e antigen</topic><topic>Hepatitis B e Antigens - blood</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B, Chronic - enzymology</topic><topic>Hepatitis B, Chronic - immunology</topic><topic>Hepatitis B, Chronic - pathology</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Liver Cirrhosis - enzymology</topic><topic>Liver Cirrhosis - immunology</topic><topic>Liver Cirrhosis - pathology</topic><topic>liver fibrosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halfon, P.</creatorcontrib><creatorcontrib>Bourlière, M.</creatorcontrib><creatorcontrib>Pol, S.</creatorcontrib><creatorcontrib>Benhamou, Y.</creatorcontrib><creatorcontrib>Ouzan, D.</creatorcontrib><creatorcontrib>Rotily, M.</creatorcontrib><creatorcontrib>Khiri, H.</creatorcontrib><creatorcontrib>Renou, C.</creatorcontrib><creatorcontrib>Pénaranda, G.</creatorcontrib><creatorcontrib>Saadoun, D.</creatorcontrib><creatorcontrib>Thibault, V.</creatorcontrib><creatorcontrib>Serpaggi, J.</creatorcontrib><creatorcontrib>Varastet, M.</creatorcontrib><creatorcontrib>Tainturier, M.-H.</creatorcontrib><creatorcontrib>Poynard, T.</creatorcontrib><creatorcontrib>Cacoub, P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of viral hepatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halfon, P.</au><au>Bourlière, M.</au><au>Pol, S.</au><au>Benhamou, Y.</au><au>Ouzan, D.</au><au>Rotily, M.</au><au>Khiri, H.</au><au>Renou, C.</au><au>Pénaranda, G.</au><au>Saadoun, D.</au><au>Thibault, V.</au><au>Serpaggi, J.</au><au>Varastet, M.</au><au>Tainturier, M.-H.</au><au>Poynard, T.</au><au>Cacoub, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multicentre study of hepatitis B virus genotypes in France: correlation with liver fibrosis and hepatitis B e antigen status</atitle><jtitle>Journal of viral hepatitis</jtitle><addtitle>J Viral Hepat</addtitle><date>2006-05</date><risdate>2006</risdate><volume>13</volume><issue>5</issue><spage>329</spage><epage>335</epage><pages>329-335</pages><issn>1352-0504</issn><eissn>1365-2893</eissn><abstract>The clinical significance of hepatitis B virus (HBV) genotypes is still under debate. The aims of this study were to assess the distribution of HBV genotypes in France and to identify the associations between HBV genotypes and patient demographics, severity of liver disease and HBeAg status in patients referred to tertiary care centres. This was a French, multicentre, retrospective study on 262 patients with chronic HBV infection. HBV genotypes were determined using INNO‐LiPA. Liver fibrosis damage was evaluated by histological analysis of biopsy samples. Patients were mainly male (74%), of Caucasian (65%), Asian (17%) or African (18%) ethnicity and 36% were HBeAg positive. All A–G genotypes were found, the most frequent being genotypes D (27%) and A (24%), followed by E (13%) and C (12%), and B (7%). Mixed genotypes were detected in 16% of the cases. Genotype A was associated with sexual contact (P < 0.001) and genotype D with transfusion (P < 0.001) and HBe antibody positivity (P = 0.03).The distribution of HBV genotypes differed with regard to the ethnicity, and may reflect migration patterns. Genotypes A and D were the most frequent in France. Genotype A was associated with HBeAg positivity and genotype D with HBe antibody positivity. In our European patients, we find no clear association between a given HBV genotype and liver disease severity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16637864</pmid><doi>10.1111/j.1365-2893.2005.00692.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of viral hepatitis, 2006-05, Vol.13 (5), p.329-335 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Alanine Transaminase - blood Cross-Sectional Studies epidemiology Female France Genotype hepatitis B hepatitis B e antigen Hepatitis B e Antigens - blood Hepatitis B Surface Antigens - blood Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B, Chronic - enzymology Hepatitis B, Chronic - immunology Hepatitis B, Chronic - pathology Hepatitis B, Chronic - virology Histocytochemistry Humans Liver Cirrhosis - enzymology Liver Cirrhosis - immunology Liver Cirrhosis - pathology liver fibrosis Male Middle Aged Retrospective Studies |
| title | Multicentre study of hepatitis B virus genotypes in France: correlation with liver fibrosis and hepatitis B e antigen status |
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