Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines

The High- and Low-Alcohol Preferring (HAP1/LAP1 and HAP2/LAP2) mouse lines were developed by selective breeding for differences in alcohol preference. They represent the only extant selectively bred mouse lines developed for this alcohol phenotype. Therefore, they provide a unique resource for QTL d...

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Bibliographic Details
Published in:Behavior genetics 2006-03, Vol.36 (2), p.248-260
Main Authors: Bice, Paula J, Foroud, Tatiana, Carr, Lucinda G, Zhang, Lili, Liu, Lixiang, Grahame, Nicholas J, Lumeng, Lawrence, Li, Ting-Kai, Belknap, John K
Format: Article
Language:English
Subjects:
Alcohol Drinking - genetics
Alcohol Drinking - psychology
Alcoholism
Alleles
Animals
Choice Behavior - physiology
Chromosome Mapping
Chromosomes
Chromosomes, Mammalian - genetics
Female
Gene Frequency - genetics
Genetics
Genomes
Genotype & phenotype
Lod Score
Male
Medicine
Mice
Microsatellite Repeats - genetics
Quantitative Trait Loci - genetics
Selection, Genetic
Sex Factors
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Summary:The High- and Low-Alcohol Preferring (HAP1/LAP1 and HAP2/LAP2) mouse lines were developed by selective breeding for differences in alcohol preference. They represent the only extant selectively bred mouse lines developed for this alcohol phenotype. Therefore, they provide a unique resource for QTL detection and mapping. Importantly, neither of the replicate lines is inbred and therefore, novel study designs can be employed to detect loci contributing to alcohol preference. Two independent studies, with very different approaches, were conducted in the HAP and LAP replicate lines. In Study 1, microsatellite markers were genotyped in the replicate HAP1/LAP1 and HAP2/LAP2 mice in QTL regions nominated by other mouse RI and F2 studies in order to detect divergence of allele frequencies in the two oppositely selected lines. Significant differences in allele frequencies were observed in the HAP1/LAP1 mice with markers on chromosome 9 (p
ISSN:0001-8244
1573-3297
DOI:10.1007/s10519-005-9019-6