Antibacterial effect of plant extracts against Helicobacter pylori

• Published in: Phytotherapy research 2005-03, Vol.19 (3), p.198-202
• Main Authors: Nostro, A, Cellini, L, Di Bartolomeo, S, Di Campli, E, Grande, R, Cannatelli, M.A, Marzio, L, Alonzo, V
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; antibacterial activity; antibacterial properties; Biological and medical sciences; Cuminum; General pharmacology; Helicobacter pylori; Helicobacter pylori - drug effects; Humans; Medical sciences; medicinal plants; Microbial Sensitivity Tests; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; plant extracts; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Propolis; susceptibility tests
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.1640

The aim of this work was to evaluate the antibacterial effect of plant extracts as alternative and[sol ]or as active agents supporting antibiotics for treating Helicobacter pylori infection. The effect of either, ethanolic or aqueous extracts from 17 plant materials were studied against one H. pylori standard strain and 11 clinical isolates using a disc diffusion test and by evaluating the minimum inhibitory concentration (MIC) on solid media. An inhibitory activity against H. pylori strains was recorded in a large percentage of tested plants. MIC values of ethanolic extracts were from two to four concentration steps lower than the aqueous ones. In particular, ethanolic extracts of Cuminum cyminum L. and Propolis expressed MIC90 values of 0.075 mg[sol ]mL. The results show a significant in vitro effect of plant extracts against H. pylori that could be considered a valuable support in the treatment of the infection and may contribute to the development of new and safe agents for inclusion in anti‐H. pylori regimens. Copyright © 2005 John Wiley & Sons, Ltd.