Teaching molecular genetics: Chapter 3--Proteomics in nephrology

The novel discipline of proteomics has experienced a rapid growth in the recent past and has great potentials for the future. The study of proteins on a genomic scale enables a large number of proteins to be analysed simultaneously. Moreover, proteomic analysis reveals the presence of protein isofor...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2006-05, Vol.21 (5), p.611-618
Main Authors: Groenen, Patricia J T A, van den Heuvel, Lambert P W J
Format: Article
Language:English
Subjects:
Biomarkers - analysis
Biomarkers - urine
Chromatography, Liquid
Disease
Electrophoresis, Gel, Two-Dimensional
Humans
Identification
Kidney Diseases - physiopathology
Mass Spectrometry - methods
Medical research
Molecular Biology
Nephrology
Physiology
Polypeptides
Protein Array Analysis
Proteins
Proteome - analysis
Proteomics
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Urine - chemistry
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Summary:The novel discipline of proteomics has experienced a rapid growth in the recent past and has great potentials for the future. The study of proteins on a genomic scale enables a large number of proteins to be analysed simultaneously. Moreover, proteomic analysis reveals the presence of protein isoforms and post-translational modifications, both of which have the potential to regulate protein complex formation, activity and function. As such, the assessment of the proteome, unlike genomic analysis, provides a view of biological processes at their level of occurrence. The knowledge thus gained is important not only for a better understanding of renal physiology and pathophysiology, but also for the identification of disease markers and the development of new therapies. This review applies the science of proteomics to nephrology: our aim is to give an overview of the discipline, providing background information and outlining the scope, advantages and limitations of proteomics.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-006-0064-z