Urinary creatinine excretion and protein/creatinine ratios vary by body size and gender in children

Urinary protein/creatinine ratio (Up/cr) is a simple measurement for evaluation of proteinuria. However, exact effects of body size and gender on urinary excretion of creatinine and Up/cr remain unknown. We aimed to clarify their effects. Early morning urine samples were collected from 124 children...

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Published in:Pediatric nephrology (Berlin, West) West), 2006-05, Vol.21 (5), p.683-687
Main Authors: Mori, Yukiko, Hiraoka, Masahiro, Suganuma, Narufumi, Tsukahara, Hirokazu, Yoshida, Haruyoshi, Mayumi, Mitsufumi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Body Composition
Body Height
Body Size
Body Surface Area
Child
Child, Preschool
Children & youth
Creatinine
Creatinine - urine
Female
Gender
Girls
Humans
Independent variables
Kidney diseases
Male
Proteins
Proteinuria - urine
Ratios
Regression analysis
Sex Factors
Urine
Urine - chemistry
Urogenital system
Urologic Diseases - metabolism
Urologic Diseases - physiopathology
Urologic Diseases - urine
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Summary:Urinary protein/creatinine ratio (Up/cr) is a simple measurement for evaluation of proteinuria. However, exact effects of body size and gender on urinary excretion of creatinine and Up/cr remain unknown. We aimed to clarify their effects. Early morning urine samples were collected from 124 children with urinary tract disorders. Urinary hourly excretion of creatinine, Ucr (in milligrams per hour), urinary hourly excretion of protein per body surface area, Up (milligrams per square meter per hour), and Up/cr (milligrams per milligram) were calculated. Effects of gender, age, body height, body weight and body surface area on Ucr and Up/cr were analyzed, respectively, in a multiple linear regression model. Body surface area and gender affected Ucr (r2=0.842, P
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-005-0001-6