Structure and stability of columnar cyclomaltooctaose (γ-cyclodextrin) hydrate

[Display omitted] Rapid recrystallization of cyclomaltooctaose (γ-cyclodextrin, γ-CD) from aqueous solution resulted in formation of a columnar structure with only water as the guest molecule. Upon vacuum drying at 90 °C for 15 h, γ-CD, which was initially in the columnar structure, became amorphous...

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Bibliographic Details
Published in:Carbohydrate research 2005-07, Vol.340 (9), p.1631-1637
Main Authors: Hunt, Marcus A., Rusa, Cristian C., Tonelli, Alan E., Maurice Balik, C.
Format: Article
Language:English
Subjects:
Crystallization
gamma-Cyclodextrins - chemistry
Molecular Structure
Phase transformation
Solutions - chemistry
Water - chemistry
Water vapor sorption
Wide-angle X-ray diffraction
X-Ray Diffraction
γ-Cyclodextrin
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Summary:[Display omitted] Rapid recrystallization of cyclomaltooctaose (γ-cyclodextrin, γ-CD) from aqueous solution resulted in formation of a columnar structure with only water as the guest molecule. Upon vacuum drying at 90 °C for 15 h, γ-CD, which was initially in the columnar structure, became amorphous. Complementary water vapor sorption and wide-angle X-ray diffractometry experiments were performed on columnar γ-CD in its vacuum dried and as-precipitated states to elucidate its stability in humid environments and the crystal structure present at varying sorption levels. These experiments show that both types of γ-CD transform to the cage crystal structure upon exposure to water vapor at 40 °C and with an activity of 1.0. Sorption equilibrium is reached long before the crystal structure transformation is complete, indicating that a significant amount of molecular mobility exists in the various hydrated γ-CD crystal structures.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2005.03.021