Soluble Single-Molecule Nanogels of Controlled Structure as a Matrix for Efficient Artificial Enzymes

Copy cats! Soluble single‐molecule nanogels (see STEM micrograph; scalebar=20 nm) with a densely packed structure are prepared by a new method, and for the first time efficient molecular imprinting is possible. These nanogels with defined molecular weights of, for example, 40 000 Da, low polydispers...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2006-04, Vol.45 (18), p.2955-2958
Main Authors: Wulff, Günter, Chong, Byong-Oh, Kolb, Ute
Format: Article
Language:English
Subjects:
Catalysis
enzyme models
homogeneous catalysis
Microscopy, Electron, Transmission
molecular imprinting
Molecular Structure
Molecular Weight
nanogels
Polyethylene Glycols - chemistry
Polyethyleneimine - chemistry
reaction kinetics
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Summary:Copy cats! Soluble single‐molecule nanogels (see STEM micrograph; scalebar=20 nm) with a densely packed structure are prepared by a new method, and for the first time efficient molecular imprinting is possible. These nanogels with defined molecular weights of, for example, 40 000 Da, low polydispersities, and on average one active site per particle proved to be catalytically active enzyme mimics.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200503926