Linear Sesquiterpene Lactones from Anthemis auriculata and Their Antibacterial Activity

Three linear sesquiterpene lactones, anthecotulide (1), hydroxyanthecotulide (2), and acetoxyanthecotulide (3), were isolated from the aerial parts of Anthemis auriculata. Five known flavonoids, taraxa-20(30)en-3beta-ol (4), and methyl vanillate (5) were also isolated. The structures and the relativ...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2006-04, Vol.69 (4), p.662-664
Main Authors: THEODORI, Revecca, KARIOTI, Anastasia, RANČIć, Ana, SKALTSA, Helen
Format: Article
Language:English
Subjects:
Anthemis
Anthemis - chemistry
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
Biological and medical sciences
Candida albicans - drug effects
Flavonoids - chemistry
Flavonoids - isolation & purification
Flavonoids - pharmacology
General pharmacology
Gram-Positive Bacteria - drug effects
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Medical sciences
Microbial Sensitivity Tests
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
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Summary:Three linear sesquiterpene lactones, anthecotulide (1), hydroxyanthecotulide (2), and acetoxyanthecotulide (3), were isolated from the aerial parts of Anthemis auriculata. Five known flavonoids, taraxa-20(30)en-3beta-ol (4), and methyl vanillate (5) were also isolated. The structures and the relative configuration of the new compounds 2 and 3 were deduced by spectroscopic methods. The in vitro activity of compounds 1-5 against 10 bacterial species and one fungus was tested using the microdilution method.
ISSN:0163-3864
1520-6025
DOI:10.1021/np058084i