Galanin impairs performance on learning and memory tasks: Findings from galanin transgenic and GAL-R1 knockout mice

Galanin (GAL) impairs performance on cognitive tasks when administered centrally to rats. GAL transgenic (GAL-tg) mice overexpressing endogenous GAL show deficits on the probe trial of the Morris water maze spatial learning task, on the social transmission of food preference olfactory memory task, a...

Full description

Saved in:
Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2005-06, Vol.39 (3), p.239-243
Main Authors: Rustay, Nathan R., Wrenn, Craige C., Kinney, Jefferson W., Holmes, Andrew, Bailey, Kathleen R., Sullivan, Timothy L., Harris, Ashley P., Long, Katharine C., Saavedra, Maria C., Starosta, Grzegorz, Innerfield, Caitlin E., Yang, Rebecca J., Dreiling, Jennifer L., Crawley, Jacqueline N.
Format: Article
Language:English
Subjects:
Alzheimers disease
Animals
Biological and medical sciences
Cognition Disorders - physiopathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Fear conditioning
Fundamental and applied biological sciences. Psychology
Galanin
Galanin - genetics
Galanin - metabolism
Learning
Maze Learning - physiology
Medical sciences
Memory
Memory - physiology
Mice
Mice, Knockout
Mice, Transgenic
Neurology
Peptide overexpression
Receptor subtypes
Receptor, Galanin, Type 1 - genetics
Receptor, Galanin, Type 1 - metabolism
Transgenic mice
Vertebrates: endocrinology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Galanin (GAL) impairs performance on cognitive tasks when administered centrally to rats. GAL transgenic (GAL-tg) mice overexpressing endogenous GAL show deficits on the probe trial of the Morris water maze spatial learning task, on the social transmission of food preference olfactory memory task, and on the trace cued fear conditioning emotional learning and memory task. Knockout mice deficient in the GAL-R1 receptor subtype were normal on most memory tasks, while showing a small deficit in trace cued fear conditioning, suggesting a selective role for the GAL-R1 in aversive memories, and implicating other GAL receptor subtypes in spatial learning and olfactory social memory. The growing body of rodent literature implicating excess GAL in cognitive impairment is relevant to the overexpression of GAL in the basal forebrain during the progression of Alzheimer’s disease.
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2004.12.026