Using Nonnatural Amino Acids to Control Metal-Coordination Number in Three-Stranded Coiled Coils

It isn't natural: TRI peptides can selectively control the coordination number of a metal center by changing only one of the amino acids in the primary sequence. Replacement of the cysteine residue with penicillamine leads to a three‐coordinate complex CdIIS3, whereas substitution of alanine fo...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2006-04, Vol.45 (18), p.2864-2868
Main Authors: Lee, Kyung-Hoon, Cabello, Chris, Hemmingsen, Lars, Marsh, E. Neil G., Pecoraro, Vincent L.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
amino acids
Amino Acids - chemistry
Biological Products - chemistry
cadmium
Catalysis
coordination modes
Magnetic Resonance Spectroscopy
metalloproteins
Metals - chemistry
Models, Molecular
Molecular Sequence Data
peptides
Protein Structure, Tertiary
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Summary:It isn't natural: TRI peptides can selectively control the coordination number of a metal center by changing only one of the amino acids in the primary sequence. Replacement of the cysteine residue with penicillamine leads to a three‐coordinate complex CdIIS3, whereas substitution of alanine for leucine gives four‐coordinate CdS3O (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200504548