Single dose of cefodizime completely eradicated multidrug-resistant strain of Neisseria gonorrhoeae in urethritis and uterine cervicitis

Cefodizime (CDZM) has strong antimicrobial activity to Neisseria gonorrhoeae in vitro. However, multidrug-resistant N. gonorrhoea emerged and has been increasing in Japan. To know the effectiveness of CDZM on gonococcal urethritis and uterine cervicitis even in the era of multidrug-resistant N. gono...

Full description

Saved in:
Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2006-04, Vol.12 (2), p.97-99
Main Authors: Matsumoto, Tetsuro, Muratani, Tetsuro, Takahashi, Koichi, Ando, Yukiko, Sato, Yumiko, Kurashima, Masako, Yokoo, Daisuke, Ikuyama, Toshihiro, Shimokawa, Hiroshi, Yanai, Shigeaki
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Cefotaxime - analogs & derivatives
Cefotaxime - therapeutic use
Drug Resistance, Multiple, Bacterial
Female
Gonorrhea - drug therapy
Gonorrhea - microbiology
Humans
Microbial Sensitivity Tests
Neisseria gonorrhoeae
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - isolation & purification
Urethritis - drug therapy
Urethritis - microbiology
Uterine Cervicitis - drug therapy
Uterine Cervicitis - microbiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cefodizime (CDZM) has strong antimicrobial activity to Neisseria gonorrhoeae in vitro. However, multidrug-resistant N. gonorrhoea emerged and has been increasing in Japan. To know the effectiveness of CDZM on gonococcal urethritis and uterine cervicitis even in the era of multidrug-resistant N. gonorrhoeae, a clinical trial of single-dose therapy of CDZM for gonococcal urethritis and uterine cervicitis was conducted. N. gonorrhoeae was eradicated from 100% of patients with gonococcal urethritis and uterine cervicitis by a single dose of CDZM. In conclusion, CDZM is one of most suitable drugs for the treatment of gonococcal genital infection in the era of multidrug-resistant N. gonorrhoeae.
ISSN:1341-321X
DOI:10.1007/s10156-006-0431-5