The Antiphospholipid Antibody Syndrome Research in Patients with Retinal Venous Occlusion

• Published in: Archives of medical research 2005-07, Vol.36 (4), p.372-375
• Main Authors: Ilhan, Fulya, Celiker, Ulku, Godekmerdan, Ahmet, Kan, Emrah
• Format: Article
• Language: English
• Subjects: Adult; Aged; Angiography; Antibodies, Anticardiolipin - immunology; Anticardiolipin antibodies (aCL); Antiphospholipid antibody syndrome; Antiphospholipid Syndrome - complications; Cardiolipins - chemistry; Cardiolipins - immunology; Cytokines - metabolism; Female; Humans; IL-1β; Immunoglobulin G - chemistry; Immunoglobulin M - chemistry; Inflammation; Interleukin-1 - metabolism; Male; Middle Aged; Retinal Vein Occlusion - complications; Thrombosis; Vascular Diseases - complications
• ISSN: 0188-4409; 1873-5487
• DOI: 10.1016/j.arcmed.2005.03.032

The antiphospholipid antibody syndrome (APAS) is a condition associated with abnormal thrombosis and the presence of anticardiolipin antibodies (aCL). Thirty-two patients (20 male and 12 female) aged between 29 and 75 years (mean ± SD: 56.4 ± 12.34) with retinal venous occlusive disease were studied. All patients with a history of venous occlusive disease within the previous 8 months were included in the study. Diagnoses were made by fundus examination and fundus fluorescein angiography (FFA). Anticardiolipin IgM and IgG antibodies, antinuclear antibodies (ANA), and IL-1β were investigated in all patients. Neither aCL-IgM nor aCL-IgG was observed as positive in this group. Only four patients were found to be ANA positive. However, serum levels of IL-1β were higher than those of controls ( p