Total Antioxidant Capacity and Levels of Epidermal Growth Factor and Nitric Oxide in Blood and Saliva of Insulin-Dependent Diabetic Patients

• Published in: Archives of medical research 2005-07, Vol.36 (4), p.376-381
• Main Authors: Astaneie, Fatemeh, Afshari, Mojgan, Mojtahedi, Alireza, Mostafalou, Sara, Zamani, Mohammad Jafar, Larijani, Bagher, Abdollahi, Mohammad
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antioxidants - metabolism; Antioxidants - pharmacology; Blood; Case-Control Studies; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - metabolism; Diabetes type 1; Epidermal growth factor; Epidermal Growth Factor - blood; Epidermal Growth Factor - metabolism; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Nitric oxide; Nitric Oxide - blood; Nitric Oxide - metabolism; Oxidative stress; Prognosis; Saliva; Saliva - metabolism; Thiobarbituric Acid Reactive Substances
• ISSN: 0188-4409; 1873-5487
• DOI: 10.1016/j.arcmed.2005.03.007

The aim of this study was to examine how type 1 diabetic patients have altered levels of lipid peroxidation, antioxidant defense, NO and EGF in their plasma and saliva. We tested the differences in lipid peroxidation level, antioxidant power, and concentrations of epidermal growth factor (EGF) and nitric oxide (NO) in saliva and blood of type 1 diabetic subjects in comparison to healthy control subjects. Nineteen subjects with type 1 diabetes mellitus and 19 healthy age- and sex-matched control subjects were included in the study. Blood and saliva samples were obtained and analyzed for thiobarbituric reactive substances (TBARS) as a marker of lipid peroxidation, ferric reducing ability (total antioxidant power), EGF and NO levels. TBARS levels did not show a significant difference between the two groups. Analysis of antioxidant power revealed that saliva and plasma of diabetic patients had more antioxidant power ( p