Use of nitrates in hospitalised elderly patients aged 65 and over

• Published in: La revue de medecine interne 2006-05, Vol.27 (5), p.366-368
• Main Authors: Awadi, S-O, Lauerière, L, Prinseau, J, Moulonguet-Doleris, L, Baglin, A, Rouveix, E, Hanslik, T
• Format: Article
• Language: fre
• Subjects: Aged; Aged, 80 and over; France; Hospitals, Teaching; Humans; Inpatients; Nitrates - classification; Nitrates - therapeutic use
• ISSN: 0248-8663

Nitrates are frequently prescribed drugs, although their indications are limited. We studied nitrates' prescription in elderly patients hospitalised in the internal medicine ward of a French teaching hospital. Hospitalised patients aged 65 years and more and receiving nitrates in their usual treatment were identified prospectively. A standardised questionnaire was used during a structured medical interview conducted by the same physician for all patients. Informations regarding nitrates' prescription were studied according to the actual recommendations for their use: angina in patients with contraindication to betablockers, acute myocardial infarction and acute pulmonary oedema. Among 256 hospitalised elderly patients, 49 (19% [IC95%: 15-25]) were under nitrates therapy, because of either angina pectoris, heart failure or unknown reason. Cardiologists prescribed nitrates in accordance with guidelines significantly more frequently than non-cardiologists. Transdermal treatment was used in 69% of patients. In hospitalised patients aged 65 years and more who are prescribed nitrates in their usual treatment, at least one quarter have no recommended indication for its use. As almost one fifth of patients are receiving nitrates in their usual treatment, the medicoeconomic impact of these useless prescriptions could be significant. Nitrates prescribing can be optimized by following guidelines for their use, and restraining from prescribing the transdermal treatment which is more costly and without evidence-based clinical benefit compared to the oral route.