Acute Renal Failure After Liver Transplantation: Incidence, Etiology, Therapy, and Outcome

Acute renal failure (ARF) was a frequent complication after orthotopic liver transplantation (OLT) when ARF was defined by a calculated glomerular filtration rate decrease of >50% or by a doubled serum creatinine above 2.5 mg/dL within the first week after OLT. We analyzed 1352 liver transplant r...

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Bibliographic Details
Published in:Transplantation proceedings 2006-04, Vol.38 (3), p.723-724
Main Authors: Junge, G., Schewior, L.V., Kohler, S., Neuhaus, R., Langrehr, J.M., Tullius, S., Kahl, A., Frei, U., Neuhaus, P.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - epidemiology
Acute Kidney Injury - etiology
Biological and medical sciences
Blood Urea Nitrogen
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Survival
Humans
Incidence
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - etiology
Liver Transplantation - adverse effects
Liver Transplantation - mortality
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Postoperative Complications - epidemiology
Prognosis
Renal failure
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
Tissue, organ and graft immunology
Treatment Outcome
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Summary:Acute renal failure (ARF) was a frequent complication after orthotopic liver transplantation (OLT) when ARF was defined by a calculated glomerular filtration rate decrease of >50% or by a doubled serum creatinine above 2.5 mg/dL within the first week after OLT. We analyzed 1352 liver transplant recipients in retrospective fashion with regard to the incidence, etiology, therapy, and outcome of ARF; 162 patients developed ARF within the first week after OLT (12%), among whom 157 patients (97%) were recompensated by postoperative day 28. Altogether 52 patients (32%) received an average of 6 hemodialysis treatments, excluding the 5 patients (3%) who developed end-stage renal failure. Risk factors for this complication included hepatorenal syndrome type II, a glomerular filtration rate of
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2006.01.074