Acute Renal Failure After Liver Transplantation: Incidence, Etiology, Therapy, and Outcome

• Published in: Transplantation proceedings 2006-04, Vol.38 (3), p.723-724
• Main Authors: Junge, G., Schewior, L.V., Kohler, S., Neuhaus, R., Langrehr, J.M., Tullius, S., Kahl, A., Frei, U., Neuhaus, P.
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - epidemiology; Acute Kidney Injury - etiology; Biological and medical sciences; Blood Urea Nitrogen; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Survival; Humans; Incidence; Kidney Failure, Chronic - epidemiology; Kidney Failure, Chronic - etiology; Liver Transplantation - adverse effects; Liver Transplantation - mortality; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Postoperative Complications - epidemiology; Prognosis; Renal failure; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Analysis; Tissue, organ and graft immunology; Treatment Outcome
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2006.01.074

Acute renal failure (ARF) was a frequent complication after orthotopic liver transplantation (OLT) when ARF was defined by a calculated glomerular filtration rate decrease of >50% or by a doubled serum creatinine above 2.5 mg/dL within the first week after OLT. We analyzed 1352 liver transplant recipients in retrospective fashion with regard to the incidence, etiology, therapy, and outcome of ARF; 162 patients developed ARF within the first week after OLT (12%), among whom 157 patients (97%) were recompensated by postoperative day 28. Altogether 52 patients (32%) received an average of 6 hemodialysis treatments, excluding the 5 patients (3%) who developed end-stage renal failure. Risk factors for this complication included hepatorenal syndrome type II, a glomerular filtration rate of