Effects of Anti-inflammatory Biflavonoid, Ginkgetin, on Chronic Skin Inflammation

Ginkgetin, a biflavonoid from Ginkgo biloba leaves (Ginkgoaceae), was previously demonstrated to inhibit phospholipase A2 and to suppress proinflammatory gene expression such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase. In this study, the effects of ginkgetin were examined on an...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2006, Vol.29(5), pp.1046-1049
Main Authors: Lim, Hyun, Son, Kun Ho, Chang, Hyeun Wook, Kang, Sam Sik, Kim, Hyun Pyo
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
biflavonoid
Biflavonoids - administration & dosage
Biflavonoids - therapeutic use
Chronic Disease
Dermatitis - drug therapy
Dinoprostone - biosynthesis
Dinoprostone - genetics
Edema - drug therapy
Edema - pathology
Flavonoids - administration & dosage
Flavonoids - therapeutic use
gene expression
Gene Expression Regulation
ginkgetin
Male
Mice
Mice, Inbred ICR
Reverse Transcriptase Polymerase Chain Reaction
Skin - pathology
skin inflammation
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Summary:Ginkgetin, a biflavonoid from Ginkgo biloba leaves (Ginkgoaceae), was previously demonstrated to inhibit phospholipase A2 and to suppress proinflammatory gene expression such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase. In this study, the effects of ginkgetin were examined on an animal model of chronic skin inflammation and proinflammatory gene expression. When topically applied to ICR mouse ear, ginkgetin (20—80 μg/ear/treatment) inhibited ear edema (22.8—30.5%) and prostaglandin E2 production (30.2—31.1%) induced by multiple treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) for 7 consecutive days. By histological comparison, ginkgetin was also found to reduce epidermal hyperplasia. The expression of proinflammatory gene, interleukin-1β, was suppressed by ginkgetin. From the results, it is suggested that ginkgetin may be beneficial against chronic skin inflammatory disorders like atopic dermatitis.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.29.1046