Effects of Weight Loss After Gastric Bypass on Right and Left Ventricular Function Assessed by Tissue Doppler Imaging

• Published in: The American journal of cardiology 2005-06, Vol.95 (12), p.1521-1524
• Main Authors: Willens, Howard J., Chakko, Simon C., Byers, Patricia, Chirinos, Julio A., Labrador, Eugenio, Castrillon, Juan C., Lowery, Maureen H.
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Blood Flow Velocity - physiology; Cardiology. Vascular system; Echocardiography, Doppler, Color; Female; Follow-Up Studies; Gastric Bypass; Heart; Heart Ventricles - diagnostic imaging; Humans; Male; Medical imaging; Medical sciences; Mitral Valve - diagnostic imaging; Myocardial Contraction - physiology; Obesity, Morbid - surgery; Postoperative Period; Tricuspid Valve - diagnostic imaging; Ventricular Function; Ventricular Function, Left - physiology; Ventricular Function, Right - physiology; Weight control; Weight Loss - physiology
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2005.02.029

To evaluate the effects of substantial weight loss on tissue Doppler imaging parameters of right ventricular (RV) and left ventricular (LV) systolic and diastolic function, we performed standard echocardiography and tissue Doppler imaging in 17 patients with severe obesity before and after gastric bypass. Patients lost 39 ± 10 kg over 7.6 ± 3.6 months. Adjusted LV mass decreased (134 ± 41 to 119 ± 31 kg/m, p = 0.031). After weight loss, the ratios of early-to-late diastolic mitral and tricuspid inflow velocities increased (1.3 ± 0.2 to 1.6 ± 0.5, p = 0.02; 1.0 ± 0.1 to 1.6 ± 0.3, p = 0.003). Early diastolic tissue Doppler velocities increased at both the lateral and septal mitral annulus (7.6 ± 1.5 to 9.3 ± 2.5 cm/s, p = 0.009; and 6.6 ± 1.4 to 7.7 ± 1.7 cm/s; p = 0.028, respectively) and for their 2-site average (7.2 ± 1.0 to 8.5 ± 1.7 cm/s, p = 0.007). Early diastolic tricuspid annular velocity increased (7.2 ± 2.8 to 10.6 ± 2.3 cm/s, p