Stromal niches, plasma cell differentiation and survival

Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switching of plasma cell precursors as well as on the lifespan of the antibody-secreting cells. Induction of tissue-specific chemokine receptors and adhesion...

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Bibliographic Details
Published in:Current Opinion in Immunology 2006-06, Vol.18 (3), p.265-270
Main Authors: Moser, Katrin, Tokoyoda, Koji, Radbruch, Andreas, MacLennan, Ian, Manz, Rudolf A
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - immunology
Cell Survival - immunology
Humans
Models, Immunological
Plasma Cells - cytology
Plasma Cells - immunology
Signal Transduction - immunology
Stromal Cells - cytology
Stromal Cells - immunology
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Summary:Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switching of plasma cell precursors as well as on the lifespan of the antibody-secreting cells. Induction of tissue-specific chemokine receptors and adhesion molecules directs migratory plasma cell precursors to tissues close to those in which the original immune stimulation occurred. This mechanism focuses the production of specific antibodies within a particular type of tissue, thus providing a means for the most efficient protection against tissue-specific pathogens. Relocation does not apply to long-lived plasma cells responsible for sustained titers of high-affinity systemic antibody. These are formed in germinal centers and migrate to specific niches in the bone marrow that support their further differentiation and long-term survival.
ISSN:0952-7915
1879-0372
1365-2567
DOI:10.1016/j.coi.2006.03.004