Deep brain stimulation of the subthalamic nucleus reversibly deteriorates stuttering in advanced Parkinson's disease

The etiology of developmental stuttering is still unknown. In some patients, stuttering re-emerges or is aggravated with the onset of Parkinson's disease (PD). We here report on a patient with PD treated by deep brain stimulation of the subthalamic nucleus and severe deterioration of stuttering...

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Bibliographic Details
Published in:Journal of Neural Transmission 2006-05, Vol.113 (5), p.625-631
Main Authors: Burghaus, L, Hilker, R, Thiel, A, Galldiks, N, Lehnhardt, F G, Zaro-Weber, O, Sturm, V, Heiss, W-D
Format: Article
Language:English
Subjects:
Antiparkinson Agents - therapeutic use
Deep Brain Stimulation - methods
Humans
Male
Middle Aged
Parkinsonian Disorders - complications
Parkinsonian Disorders - diagnostic imaging
Parkinsonian Disorders - therapy
Positron-Emission Tomography - methods
Stuttering - diagnostic imaging
Stuttering - etiology
Stuttering - therapy
Subthalamic Nucleus - diagnostic imaging
Subthalamic Nucleus - drug effects
Subthalamic Nucleus - radiation effects
Time Factors
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Summary:The etiology of developmental stuttering is still unknown. In some patients, stuttering re-emerges or is aggravated with the onset of Parkinson's disease (PD). We here report on a patient with PD treated by deep brain stimulation of the subthalamic nucleus and severe deterioration of stuttering under effective stimulation. Positron emission tomography (PET) of regional cerebral blood flow (rCBF) in stimulation on- and off-conditions showed overactivation of cerebral and cerebellar motor systems during speech activation and was in line with recent PET studies investigating brain activation during stuttering. The abnormal rCBF pattern increased in the stimulation on-condition and was associated with a marked worsening of stuttering. Clinical and imaging findings in this patient support the hypothesis that the basal ganglia circuitry plays an important role in the pathophysiology of stuttering.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-005-0341-1