Loading…

Cytokine levels in healthy and allergic mothers and their children during the first year of life

To assess the regulatory changes of immune system in children genetically pre‐disposed to allergic diseases and in their mothers, we tested cytokines IL‐4, IL‐5, IL‐6, IL‐10, IL‐13, IFN‐γ and TGF‐β in 21 healthy and 21 allergic mothers (serum at the time of delivery, colostrum and milk throughout th...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric allergy and immunology 2006-05, Vol.17 (3), p.175-183
Main Authors: PROKESOVA, Ludmila, LODINOVA-ZADNIKOVA, Raja, ZIZKA, Jan, KOCOURKOVA, Ingrid, NOVOTNA, Olga, PETRASKOVA, Petra, STERZL, Ivan
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4655-cea878c6e1772fe390869da804ae149059af581601c8b82d852a01853c815a33
cites cdi_FETCH-LOGICAL-c4655-cea878c6e1772fe390869da804ae149059af581601c8b82d852a01853c815a33
container_end_page 183
container_issue 3
container_start_page 175
container_title Pediatric allergy and immunology
container_volume 17
creator PROKESOVA, Ludmila
LODINOVA-ZADNIKOVA, Raja
ZIZKA, Jan
KOCOURKOVA, Ingrid
NOVOTNA, Olga
PETRASKOVA, Petra
STERZL, Ivan
description To assess the regulatory changes of immune system in children genetically pre‐disposed to allergic diseases and in their mothers, we tested cytokines IL‐4, IL‐5, IL‐6, IL‐10, IL‐13, IFN‐γ and TGF‐β in 21 healthy and 21 allergic mothers (serum at the time of delivery, colostrum and milk throughout the suckling period) and their children (cord blood, venous blood and stool filtrates) up to 1 yr of age. Samples were taken at the time of delivery, 4 days post‐partum and then after 3, 6 and 12 months. Significant differences between the healthy and the allergic group were found in the levels of IL‐4, IL‐10, IL‐13 and IFN‐γ. The levels of IL‐4 in the allergic group were generally higher; the levels in the sera of children of allergic mothers during the post‐natal life decreased, reaching levels typical for the healthy group at 1 yr of age. Allergic mothers exhibited markedly higher IL‐10 levels in the serum at the time of delivery and in milk 3 months after delivery than healthy mothers while after 6 months the IL‐10 levels in all samples from the allergic group were very low. Children from allergic group had lower intestinal content of IL‐13 in comparison with the healthy counterparts. At 1 yr of age, the levels of IFN‐γ in sera and stool of children from the allergic group sharply increased. TGF‐β levels in the sera of both groups were high, while in the milk they were relatively low and substantially lower that in the children's stool. TGF‐β of mammary secretions is therefore unlikely to exert a decisive regulatory influence on the children's immunity. Long‐term clinical monitoring of the children will be performed to evaluate the potential prognostic significance of these changes for the future development of allergies.
doi_str_mv 10.1111/j.1399-3038.2006.00395.x
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67928738</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67928738</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4655-cea878c6e1772fe390869da804ae149059af581601c8b82d852a01853c815a33</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhS1ERYeBv4C8gV2CHccviU0Z6ANVLUiVujSuc9Px1JMUO0Mn_x6nM2qX1BtfXX_Hvj4HIUxJSfP6vCop07pghKmyIkSUhDDNy-0rNHs6eI1mRBNeCMrlIXqb0ooQKpmgb9AhFUJmHZuh34tx6O98BzjAXwgJ-w4vwYZhOWLbNdiGAPHWO7zuhyXE9NjMlY_YLX1oInS42UTf3U5d3PqYBjyCjbhvcfAtvEMHrQ0J3u_3Obo6_n61OC3OL0_OFkfnhasF54UDq6RyAqiUVQtMEyV0YxWpLdA6_0PblisqCHXqRlWN4pUlVHHmFOWWsTn6tLv2PvZ_NpAGs_bJQQi2g36TjJC6UpKp_4JU17VgGZ0jtQNd7FOK0Jr76Nc2joYSM6VgVmYy20xmmykF85iC2Wbph_0bm5s1NM_Cve0Z-LgHbHI2tNF2zqdnTkqhKzbN8GXHPfgA44sHMD-PznKR5cVO7tMA2ye5jXfZDya5ub44MfT0xzX5yn6Zb-wfoUmwwg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19446387</pqid></control><display><type>article</type><title>Cytokine levels in healthy and allergic mothers and their children during the first year of life</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>PROKESOVA, Ludmila ; LODINOVA-ZADNIKOVA, Raja ; ZIZKA, Jan ; KOCOURKOVA, Ingrid ; NOVOTNA, Olga ; PETRASKOVA, Petra ; STERZL, Ivan</creator><creatorcontrib>PROKESOVA, Ludmila ; LODINOVA-ZADNIKOVA, Raja ; ZIZKA, Jan ; KOCOURKOVA, Ingrid ; NOVOTNA, Olga ; PETRASKOVA, Petra ; STERZL, Ivan</creatorcontrib><description>To assess the regulatory changes of immune system in children genetically pre‐disposed to allergic diseases and in their mothers, we tested cytokines IL‐4, IL‐5, IL‐6, IL‐10, IL‐13, IFN‐γ and TGF‐β in 21 healthy and 21 allergic mothers (serum at the time of delivery, colostrum and milk throughout the suckling period) and their children (cord blood, venous blood and stool filtrates) up to 1 yr of age. Samples were taken at the time of delivery, 4 days post‐partum and then after 3, 6 and 12 months. Significant differences between the healthy and the allergic group were found in the levels of IL‐4, IL‐10, IL‐13 and IFN‐γ. The levels of IL‐4 in the allergic group were generally higher; the levels in the sera of children of allergic mothers during the post‐natal life decreased, reaching levels typical for the healthy group at 1 yr of age. Allergic mothers exhibited markedly higher IL‐10 levels in the serum at the time of delivery and in milk 3 months after delivery than healthy mothers while after 6 months the IL‐10 levels in all samples from the allergic group were very low. Children from allergic group had lower intestinal content of IL‐13 in comparison with the healthy counterparts. At 1 yr of age, the levels of IFN‐γ in sera and stool of children from the allergic group sharply increased. TGF‐β levels in the sera of both groups were high, while in the milk they were relatively low and substantially lower that in the children's stool. TGF‐β of mammary secretions is therefore unlikely to exert a decisive regulatory influence on the children's immunity. Long‐term clinical monitoring of the children will be performed to evaluate the potential prognostic significance of these changes for the future development of allergies.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/j.1399-3038.2006.00395.x</identifier><identifier>PMID: 16672003</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Breast Feeding ; breast feeding and allergy ; children's blood and stool ; Colostrum - metabolism ; cytokines ; Cytokines - blood ; Cytokines - metabolism ; Feces - chemistry ; Female ; Fetal Blood - metabolism ; Humans ; Hypersensitivity - blood ; Hypersensitivity - metabolism ; Immunopathology ; Infant ; Infant, Newborn ; Interferon-gamma - blood ; Interferon-gamma - metabolism ; Interleukin-10 - blood ; Interleukin-10 - metabolism ; Interleukin-13 - metabolism ; Interleukin-4 - blood ; Interleukin-4 - metabolism ; maternal milk ; Medical sciences ; Milk, Human - metabolism ; Pregnancy</subject><ispartof>Pediatric allergy and immunology, 2006-05, Vol.17 (3), p.175-183</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4655-cea878c6e1772fe390869da804ae149059af581601c8b82d852a01853c815a33</citedby><cites>FETCH-LOGICAL-c4655-cea878c6e1772fe390869da804ae149059af581601c8b82d852a01853c815a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=17769237$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16672003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PROKESOVA, Ludmila</creatorcontrib><creatorcontrib>LODINOVA-ZADNIKOVA, Raja</creatorcontrib><creatorcontrib>ZIZKA, Jan</creatorcontrib><creatorcontrib>KOCOURKOVA, Ingrid</creatorcontrib><creatorcontrib>NOVOTNA, Olga</creatorcontrib><creatorcontrib>PETRASKOVA, Petra</creatorcontrib><creatorcontrib>STERZL, Ivan</creatorcontrib><title>Cytokine levels in healthy and allergic mothers and their children during the first year of life</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>To assess the regulatory changes of immune system in children genetically pre‐disposed to allergic diseases and in their mothers, we tested cytokines IL‐4, IL‐5, IL‐6, IL‐10, IL‐13, IFN‐γ and TGF‐β in 21 healthy and 21 allergic mothers (serum at the time of delivery, colostrum and milk throughout the suckling period) and their children (cord blood, venous blood and stool filtrates) up to 1 yr of age. Samples were taken at the time of delivery, 4 days post‐partum and then after 3, 6 and 12 months. Significant differences between the healthy and the allergic group were found in the levels of IL‐4, IL‐10, IL‐13 and IFN‐γ. The levels of IL‐4 in the allergic group were generally higher; the levels in the sera of children of allergic mothers during the post‐natal life decreased, reaching levels typical for the healthy group at 1 yr of age. Allergic mothers exhibited markedly higher IL‐10 levels in the serum at the time of delivery and in milk 3 months after delivery than healthy mothers while after 6 months the IL‐10 levels in all samples from the allergic group were very low. Children from allergic group had lower intestinal content of IL‐13 in comparison with the healthy counterparts. At 1 yr of age, the levels of IFN‐γ in sera and stool of children from the allergic group sharply increased. TGF‐β levels in the sera of both groups were high, while in the milk they were relatively low and substantially lower that in the children's stool. TGF‐β of mammary secretions is therefore unlikely to exert a decisive regulatory influence on the children's immunity. Long‐term clinical monitoring of the children will be performed to evaluate the potential prognostic significance of these changes for the future development of allergies.</description><subject>Biological and medical sciences</subject><subject>Breast Feeding</subject><subject>breast feeding and allergy</subject><subject>children's blood and stool</subject><subject>Colostrum - metabolism</subject><subject>cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - metabolism</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Humans</subject><subject>Hypersensitivity - blood</subject><subject>Hypersensitivity - metabolism</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Interferon-gamma - blood</subject><subject>Interferon-gamma - metabolism</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-10 - metabolism</subject><subject>Interleukin-13 - metabolism</subject><subject>Interleukin-4 - blood</subject><subject>Interleukin-4 - metabolism</subject><subject>maternal milk</subject><subject>Medical sciences</subject><subject>Milk, Human - metabolism</subject><subject>Pregnancy</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkUtv1DAUhS1ERYeBv4C8gV2CHccviU0Z6ANVLUiVujSuc9Px1JMUO0Mn_x6nM2qX1BtfXX_Hvj4HIUxJSfP6vCop07pghKmyIkSUhDDNy-0rNHs6eI1mRBNeCMrlIXqb0ooQKpmgb9AhFUJmHZuh34tx6O98BzjAXwgJ-w4vwYZhOWLbNdiGAPHWO7zuhyXE9NjMlY_YLX1oInS42UTf3U5d3PqYBjyCjbhvcfAtvEMHrQ0J3u_3Obo6_n61OC3OL0_OFkfnhasF54UDq6RyAqiUVQtMEyV0YxWpLdA6_0PblisqCHXqRlWN4pUlVHHmFOWWsTn6tLv2PvZ_NpAGs_bJQQi2g36TjJC6UpKp_4JU17VgGZ0jtQNd7FOK0Jr76Nc2joYSM6VgVmYy20xmmykF85iC2Wbph_0bm5s1NM_Cve0Z-LgHbHI2tNF2zqdnTkqhKzbN8GXHPfgA44sHMD-PznKR5cVO7tMA2ye5jXfZDya5ub44MfT0xzX5yn6Zb-wfoUmwwg</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>PROKESOVA, Ludmila</creator><creator>LODINOVA-ZADNIKOVA, Raja</creator><creator>ZIZKA, Jan</creator><creator>KOCOURKOVA, Ingrid</creator><creator>NOVOTNA, Olga</creator><creator>PETRASKOVA, Petra</creator><creator>STERZL, Ivan</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Cytokine levels in healthy and allergic mothers and their children during the first year of life</title><author>PROKESOVA, Ludmila ; LODINOVA-ZADNIKOVA, Raja ; ZIZKA, Jan ; KOCOURKOVA, Ingrid ; NOVOTNA, Olga ; PETRASKOVA, Petra ; STERZL, Ivan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4655-cea878c6e1772fe390869da804ae149059af581601c8b82d852a01853c815a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Breast Feeding</topic><topic>breast feeding and allergy</topic><topic>children's blood and stool</topic><topic>Colostrum - metabolism</topic><topic>cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - metabolism</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Humans</topic><topic>Hypersensitivity - blood</topic><topic>Hypersensitivity - metabolism</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Interferon-gamma - blood</topic><topic>Interferon-gamma - metabolism</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-10 - metabolism</topic><topic>Interleukin-13 - metabolism</topic><topic>Interleukin-4 - blood</topic><topic>Interleukin-4 - metabolism</topic><topic>maternal milk</topic><topic>Medical sciences</topic><topic>Milk, Human - metabolism</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PROKESOVA, Ludmila</creatorcontrib><creatorcontrib>LODINOVA-ZADNIKOVA, Raja</creatorcontrib><creatorcontrib>ZIZKA, Jan</creatorcontrib><creatorcontrib>KOCOURKOVA, Ingrid</creatorcontrib><creatorcontrib>NOVOTNA, Olga</creatorcontrib><creatorcontrib>PETRASKOVA, Petra</creatorcontrib><creatorcontrib>STERZL, Ivan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PROKESOVA, Ludmila</au><au>LODINOVA-ZADNIKOVA, Raja</au><au>ZIZKA, Jan</au><au>KOCOURKOVA, Ingrid</au><au>NOVOTNA, Olga</au><au>PETRASKOVA, Petra</au><au>STERZL, Ivan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine levels in healthy and allergic mothers and their children during the first year of life</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2006-05</date><risdate>2006</risdate><volume>17</volume><issue>3</issue><spage>175</spage><epage>183</epage><pages>175-183</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>To assess the regulatory changes of immune system in children genetically pre‐disposed to allergic diseases and in their mothers, we tested cytokines IL‐4, IL‐5, IL‐6, IL‐10, IL‐13, IFN‐γ and TGF‐β in 21 healthy and 21 allergic mothers (serum at the time of delivery, colostrum and milk throughout the suckling period) and their children (cord blood, venous blood and stool filtrates) up to 1 yr of age. Samples were taken at the time of delivery, 4 days post‐partum and then after 3, 6 and 12 months. Significant differences between the healthy and the allergic group were found in the levels of IL‐4, IL‐10, IL‐13 and IFN‐γ. The levels of IL‐4 in the allergic group were generally higher; the levels in the sera of children of allergic mothers during the post‐natal life decreased, reaching levels typical for the healthy group at 1 yr of age. Allergic mothers exhibited markedly higher IL‐10 levels in the serum at the time of delivery and in milk 3 months after delivery than healthy mothers while after 6 months the IL‐10 levels in all samples from the allergic group were very low. Children from allergic group had lower intestinal content of IL‐13 in comparison with the healthy counterparts. At 1 yr of age, the levels of IFN‐γ in sera and stool of children from the allergic group sharply increased. TGF‐β levels in the sera of both groups were high, while in the milk they were relatively low and substantially lower that in the children's stool. TGF‐β of mammary secretions is therefore unlikely to exert a decisive regulatory influence on the children's immunity. Long‐term clinical monitoring of the children will be performed to evaluate the potential prognostic significance of these changes for the future development of allergies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16672003</pmid><doi>10.1111/j.1399-3038.2006.00395.x</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0905-6157
ispartof Pediatric allergy and immunology, 2006-05, Vol.17 (3), p.175-183
issn 0905-6157
1399-3038
language eng
recordid cdi_proquest_miscellaneous_67928738
source Wiley-Blackwell Read & Publish Collection
subjects Biological and medical sciences
Breast Feeding
breast feeding and allergy
children's blood and stool
Colostrum - metabolism
cytokines
Cytokines - blood
Cytokines - metabolism
Feces - chemistry
Female
Fetal Blood - metabolism
Humans
Hypersensitivity - blood
Hypersensitivity - metabolism
Immunopathology
Infant
Infant, Newborn
Interferon-gamma - blood
Interferon-gamma - metabolism
Interleukin-10 - blood
Interleukin-10 - metabolism
Interleukin-13 - metabolism
Interleukin-4 - blood
Interleukin-4 - metabolism
maternal milk
Medical sciences
Milk, Human - metabolism
Pregnancy
title Cytokine levels in healthy and allergic mothers and their children during the first year of life
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T12%3A20%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytokine%20levels%20in%20healthy%20and%20allergic%20mothers%20and%20their%20children%20during%20the%20first%20year%20of%20life&rft.jtitle=Pediatric%20allergy%20and%20immunology&rft.au=PROKESOVA,%20Ludmila&rft.date=2006-05&rft.volume=17&rft.issue=3&rft.spage=175&rft.epage=183&rft.pages=175-183&rft.issn=0905-6157&rft.eissn=1399-3038&rft_id=info:doi/10.1111/j.1399-3038.2006.00395.x&rft_dat=%3Cproquest_cross%3E67928738%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4655-cea878c6e1772fe390869da804ae149059af581601c8b82d852a01853c815a33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=19446387&rft_id=info:pmid/16672003&rfr_iscdi=true