The presence of anti-phosphatidylserine/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus

Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka 565-0871, Japan. nojima@hplab.med.osaka-u.ac.jp In an effort to clarify the clinical significance of anti-phospholipid antibodies (aPL) detected by enzyme-linked immunosorbent assay (ELISA), we examined the prevalence of...

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Bibliographic Details
Published in:Haematologica (Roma) 2006-05, Vol.91 (5), p.699-702
Main Authors: Nojima, J, Iwatani, Y, Suehisa, E, Kuratsune, H, Kanakura, Y
Format: Article
Language:English
Subjects:
Abortion, Habitual - etiology
Abortion, Habitual - immunology
Adenosine Diphosphate - pharmacology
Adolescent
Adult
Aged
Antibodies, Anticardiolipin - blood
Antibodies, Antiphospholipid - blood
Arterial Occlusive Diseases - blood
Arterial Occlusive Diseases - epidemiology
Arterial Occlusive Diseases - immunology
Autoantibodies - blood
Autoantigens - immunology
beta 2-Glycoprotein I
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Child
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Enzyme-Linked Immunosorbent Assay
Female
Glycoproteins - immunology
Hematologic and hematopoietic diseases
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - immunology
Male
Medical sciences
Middle Aged
Phosphatidylserines - immunology
Platelet Activation - drug effects
Pregnancy
Prothrombin - immunology
Risk Factors
Thrombophilia - blood
Thrombophilia - etiology
Thrombophilia - immunology
Venous Thrombosis - blood
Venous Thrombosis - epidemiology
Venous Thrombosis - immunology
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Summary:Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka 565-0871, Japan. nojima@hplab.med.osaka-u.ac.jp In an effort to clarify the clinical significance of anti-phospholipid antibodies (aPL) detected by enzyme-linked immunosorbent assay (ELISA), we examined the prevalence of anti-cardiolipin antibodies (aCL), anti-beta2-glycoprotein I antibodies (anti-beta2-GPI), antiprothrombin antibodies (anti-PT), and anti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) in 175 patients with systemic lupus erythematosus (SLE) comprising 67 patients with thrombotic complications. The present study showed that positive results of anti-beta2-GPI-ELISA and anti-PS/PT-ELISA could serve as markers of thrombotic complications in patients with SLE, whereas aCL and anti-PT are less reliable as markers of these complications. Furthermore, results of the anti-PS/PT-ELISA correlate best with the occurrence of both arterial and venous thrombosis in patients with SLE.
ISSN:0390-6078
1592-8721