A Novel, Adenylate Cyclase, Signaling Mechanism of Relaxin H2 Action

: For the first time, the adenylate cyclase signaling mechanism (ACSM) of the action of relaxin H2 was revealed and deciphered in human and rat muscle tissues. The comparative study of signaling blocks forming the ACSM of relaxin and insulin (discovered earlier) showed that the postreceptor signalin...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-05, Vol.1041 (1), p.305-307
Main Authors: SHPAKOV, ALEXANDER, PERTSEVA, MARIANNA, KUZNETSOVA, LUDMILA, PLESNEVA, SVETLANA
Format: Article
Language:English
Subjects:
adenylate cyclase
Adenylyl Cyclases - metabolism
Animals
Cascades
Chains
Female
Human
Humans
Insulin
Insulin - pharmacology
Kinases
Muscles
Myometrium - drug effects
Myometrium - metabolism
phosphatidylinositol 3-kinase
protein kinase C
Protein Kinase C - metabolism
Proteins
Rats
Receptors
relaxin
Relaxin - pharmacology
Signal Transduction - drug effects
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Summary:: For the first time, the adenylate cyclase signaling mechanism (ACSM) of the action of relaxin H2 was revealed and deciphered in human and rat muscle tissues. The comparative study of signaling blocks forming the ACSM of relaxin and insulin (discovered earlier) showed that the postreceptor signaling chain of relaxin coincides with that of insulin. However, the type of relaxin receptor involved in ACSM remains obscure. Currently, the ACSM of relaxin may be represented as a signaling cascade: receptor ⇒ Gi protein (βγ‐dimer) ⇒ phosphatidylinositol 3‐kinase (PI3K) ⇒ protein kinase Cζ (PKCζ) ⇒ Gs protein ⇒ adenylate cyclase.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1282.046