Unique radiographic appearance of bone marrow metastasis of an insulin-secreting beta-cell carcinoma in a dog

• Published in: Journal of veterinary internal medicine 2005-05, Vol.19 (3), p.350-354
• Main Authors: Pickens, E.H, Kim, D.Y, Gaunt, S, Neer, T.M
• Format: Article
• Language: English
• Subjects: Animals; Bone Marrow Neoplasms - diagnostic imaging; Bone Marrow Neoplasms - secondary; Bone Marrow Neoplasms - veterinary; Carcinoma, Islet Cell - diagnostic imaging; Carcinoma, Islet Cell - secondary; Carcinoma, Islet Cell - veterinary; case studies; Dog Diseases - diagnostic imaging; Dogs; histopathology; humerus; Male; pancreas; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - veterinary; Radiography
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/j.1939-1676.2005.tb02707.x

A9‐year‐old, neutered male Border Collie—mix dog presented to the Louisiana State University Veterinary Teaching Hospital and Clinics (LSU‐VTH&C) for evaluation of chronic, intermittent vomiting of 6 months' duration. The episodes of vomiting, along with decreased appetite and lethargy, had occurred sporadically during these 6 months. One day before referral, episodes of acute collapse and weakness in the pelvic limbs were noticed. A CBC and serum biochemistry had been performed on several occasions during the previous 6 months by the referring veterinarian and each time, high alkaline phosphatase (ALP) activity was found. An ACTH stimulation test also had been performed 8 weeks before referral and results were normal. On 2 separate occasions, therapeutic dietary trialsa, b and symptomatic treatment with metoclopramidec (0.5 mg/kg PO q8h) did not improve the clinical signs. In addition, the dog had lost 6 pounds of body weight over the 6‐month period