Oxytocin and Estrogen Receptor Expression in the Myometrium of Pregnant Relaxin-Deficient (Rlx−/−) Mice

: Relaxin decreases oxytocin‐stimulated rat myometrial contractions in vitro. This study used pregnant relaxin‐deficient (Rlx−/−) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-05, Vol.1041 (1), p.104-109
Main Authors: SIEBEL, ANDREW L., GEHRING, HELEN M., VODSTRCIL, LENKA, PARRY, LAURA J.
Format: Article
Language:English
Subjects:
Animals
Correlation
estrogen receptor
Estrogen Receptor alpha - genetics
Estrogen Receptor beta - genetics
Estrogens
Female
Gene Expression Regulation - genetics
Gestation
In vitro testing
Mice
Mice, Knockout
myometrium
Myometrium - drug effects
Myometrium - metabolism
oxytocin receptor
Pregnancy
Pregnancy, Animal - genetics
Pregnancy, Animal - metabolism
Receptors
Receptors, G-Protein-Coupled - genetics
Receptors, Oxytocin - genetics
Relaxin - deficiency
Relaxin - genetics
Relaxin - metabolism
Relaxin - pharmacology
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Summary:: Relaxin decreases oxytocin‐stimulated rat myometrial contractions in vitro. This study used pregnant relaxin‐deficient (Rlx−/−) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx−/− mice than in Rlx+/+ mice. An increase in ERα in Rlx+/+ mice at term was correlated with a decrease in ERβ, which was not observed in Rlx−/− mice. Treatment of Rlx−/− mice with relaxin had no effect on OTR, LGR7, or ERα expression, but it caused a significant decrease in ERβs.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1282.014